PMID- 27698590
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1507-1367 (Print)
IS  - 2083-4640 (Electronic)
IS  - 1507-1367 (Linking)
VI  - 21
IP  - 6
DP  - 2016 Nov-Dec
TI  - Dosimetric feasibility of an "off-breast isocenter" technique for whole-breast 
      cancer radiotherapy.
PG  - 500-507
AB  - AIM: To investigate the viability of placing the treatment isocenter at the 
      patient midline for breast cancer radiotherapy in order to avoid the risk of 
      collisions during image-guided setup and treatment delivery. BACKGROUND: The use 
      of kilovoltage orthogonal setup images has spread in last years in breast 
      radiotherapy. There is a potential risk of an imaging system-patient collision 
      when the isocenter is laterally placed. MATERIALS AND METHODS: Twenty IMRT plans 
      designed by placing the isocenter within the breast volume ("plan_ref"), were 
      retrospectively replanned by shifting the isocenter at the patient's midline 
      ("plan_off-breast"). An integrated simultaneous boost (SIB) technique was used. 
      Multiple metrics for the planning target volumes (PTVs) and organs at risk (OARs) 
      were compared for both approaches using a paired t test. RESULTS: Comparing 
      plan_ref vs. plan_off-breast, no significant differences in PTV coverage (V95%) 
      were found (96.5% vs. 96.2%; p = 0.361 to PTVbreast; 97.0% vs. 97.0%; p = 0.977 
      to PTVtumor_bed). With regard to OARs, no substantial differences were observed 
      in any analyzed metric: V5Gy (30.3% vs. 31.4%; p = 0.486), V20Gy (10.3% vs. 
      10.3%; p = 0.903) and mean dose (7.1 Gy vs. 7.1 Gy; p = 0.924) to the ipsilateral 
      lung; V5Gy (11.2% vs. 10.0%; p = 0.459), V30Gy (0.7% vs. 0.6%; p = 0.251) and 
      mean dose (2.3 Gy vs. 2.2 Gy; p = 0.400) to the heart; and average dose to the 
      contralateral breast (0.4 Gy vs. 0.5 Gy; p = 0.107). CONCLUSIONS: The off-breast 
      isocenter solution resulted in dosimetrically comparable plans as the reference 
      technique, avoiding the collision risk during the treatment session.
FAU - Calvo-Ortega, Juan-Francisco
AU  - Calvo-Ortega JF
AD  - Servicio de Oncologia Radioterapica, Hospital Quiron Barcelona, Plaza Alfonso 
      Comin, 5, 08023 Barcelona, Spain.
FAU - Moragues, Sandra
AU  - Moragues S
AD  - Servicio de Oncologia Radioterapica, Hospital Quiron Barcelona, Plaza Alfonso 
      Comin, 5, 08023 Barcelona, Spain.
FAU - Pozo, Miquel
AU  - Pozo M
AD  - Servicio de Oncologia Radioterapica, Hospital Quiron Barcelona, Plaza Alfonso 
      Comin, 5, 08023 Barcelona, Spain.
FAU - Casals, Joan
AU  - Casals J
AD  - Servicio de Oncologia Radioterapica, Hospital Quiron Barcelona, Plaza Alfonso 
      Comin, 5, 08023 Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20160824
PL  - Poland
TA  - Rep Pract Oncol Radiother
JT  - Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer 
      Center in Poznan and Polish Society of Radiation Oncology
JID - 100885761
PMC - PMC5036509
OTO - NOTNLM
OT  - Collision
OT  - IMRT
OT  - Isocenter
OT  - Off-breast
OT  - SIB
EDAT- 2016/10/05 06:00
MHDA- 2016/10/05 06:01
PMCR- 2017/11/01
CRDT- 2016/10/05 06:00
PHST- 2016/02/25 00:00 [received]
PHST- 2016/06/26 00:00 [accepted]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2016/10/05 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - S1507-1367(16)30041-4 [pii]
AID - 10.1016/j.rpor.2016.06.001 [doi]
PST - ppublish
SO  - Rep Pract Oncol Radiother. 2016 Nov-Dec;21(6):500-507. doi: 
      10.1016/j.rpor.2016.06.001. Epub 2016 Aug 24.