PMID- 27698687
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 12
IP  - 4
DP  - 2016 Oct
TI  - Guided bone regeneration with local zoledronic acid and titanium barrier: An 
      experimental study.
PG  - 2015-2020
AB  - The aim of this study was to evaluate the effects on new bone formation of 
      autogenous blood alone or in combination with zoledronic acid (ZA), a 
      beta-tricalcium phosphate (beta-TCP) graft or ZA plus a beta-TCP graft placed under 
      titanium barriers. For this purpose, eight adult male New Zealand white rabbits 
      were used in the study, each with four titanium barriers fixed around four sets 
      of nine holes drilled in the calvarial bones. The study included four groups, 
      each containing 2 rabbits. In the autogenous blood (AB group), only autogeneous 
      blood was placed under the titanium barriers. The three experimental groups were 
      the AB+ZA group, with autogenous blood plus ZA, the AB+beta-TCP group, with 
      autogeneous blood plus a beta-TCP graft, and the AB+beta-TCP+ZA group, with autogeneous 
      blood plus a beta-TCP graft and ZA mixture under the titanium barriers. The animals 
      were sacrificed after 3 months. The amounts of new bone formation identified 
      histomorphometrically were found to be higher after 3 months than at the time of 
      surgery in all groups. The differences between the groups were examined with 
      histomorphometric analysis, and statistically significant differences were 
      identified at the end of the 3 months. The bone formation rate in the AB+beta-TCP+ZA 
      group was determined to be significantly higher than that in the other groups 
      (P<0.05). In the AB+ZA and AB+beta-TCP groups, the bone formation rate was 
      determined to be significantly higher than that in the AB group (P<0.05). No 
      statistically significant difference in bone formation rate was observed between 
      the AB+beta-TCP and AB+ZA groups. Local ZA used with autogeneous blood and/or graft 
      material appears to be a more effective method than the use of autogeneous blood 
      or graft alone in bone augmentation executed with a titanium barrier.
FAU - Dundar, Serkan
AU  - Dundar S
AD  - Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, 
      23119 Elazig, Turkey.
FAU - Ozgur, Cem
AU  - Ozgur C
AD  - Department of Oral Maxillofacial Surgery, Corlu Dental and Oral Health Centre, 
      Ministry of Health, Tekirdag, 59850 Tekirdag, Turkey.
FAU - Yaman, Ferhan
AU  - Yaman F
AD  - Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Dicle University, 
      Diyarbakir, 21280 Diyarbakir, Turkey.
FAU - Cakmak, Omer
AU  - Cakmak O
AD  - Department of Periodontology, Faculty of Dentistry, Afyon Kocatepe University, 
      Afyonkarahisar, 03200 Afyon, Turkey.
FAU - Saybak, Arif
AU  - Saybak A
AD  - Private Practice, Adana, 01220 Adana, Turkey.
FAU - Ozercan, Ibrahim Hanifi
AU  - Ozercan IH
AD  - Department of Medical Pathology, Faculty of Medicine, Firat University, Elazig, 
      23119 Elazig, Turkey.
FAU - Alan, Hilal
AU  - Alan H
AD  - Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Inonu University, 
      Malatya, 44280 Malatya, Turkey.
FAU - Artas, Gokhan
AU  - Artas G
AD  - Department of Medical Pathology, Faculty of Medicine, Firat University, Elazig, 
      23119 Elazig, Turkey.
FAU - Nacakgedigi, Onur
AU  - Nacakgedigi O
AD  - Department of Restorative Dentistry, Dicle University, Diyarbakir, 21280 
      Diyarbakir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160812
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5038562
OTO - NOTNLM
OT  - guided bone regeneration
OT  - rabbit calvarium
OT  - titanium barrier
OT  - zoledronic acid
EDAT- 2016/10/05 06:00
MHDA- 2016/10/05 06:01
PMCR- 2016/08/12
CRDT- 2016/10/05 06:00
PHST- 2015/12/23 00:00 [received]
PHST- 2016/05/27 00:00 [accepted]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2016/10/05 06:01 [medline]
PHST- 2016/08/12 00:00 [pmc-release]
AID - ETM-0-0-3598 [pii]
AID - 10.3892/etm.2016.3598 [doi]
PST - ppublish
SO  - Exp Ther Med. 2016 Oct;12(4):2015-2020. doi: 10.3892/etm.2016.3598. Epub 2016 Aug 
      12.