PMID- 27698889
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 12
IP  - 4
DP  - 2016 Oct
TI  - TGFB2 and BCL2L11 methylation in male laryngeal cancer patients.
PG  - 2999-3003
AB  - DNA methylation is a major regulatory mechanism of gene expression. The aim of 
      the present study was to test the association of transforming growth factor beta2 
      (TGFB2) and B cell lymphoma 2-like 11 (BCL2L11) gene methylation with the risk of 
      laryngeal squamous cell carcinoma (LSCC). Using bisulfite pyrosequencing 
      technology, DNA methylation levels of TGFB2 promoter and BCL2L11 gene-body CpG 
      cytosines were measured in 90 LSCC tissues and 90 adjacent normal tissues. 
      Analysis of variance and paired sample t-test were used to determine the 
      association of gene methylation and the risk of LSCC. Our results revealed that 
      there were no differences in TGFB2 and BCL2L11 methylation levels between the 
      LSCC tissues and the paired normal tissues (P>0.05). Further breakdown analyses 
      demonstrated that the association results of the two gene methylation levels and 
      LSCC remained unchanged with the age, smoking history, histological 
      differentiation or clinical stage of the LSCC patients (all adjusted P>0.05). In 
      conclusion, there is no association of TGFB2 promoter and BCL2L11 gene-body 
      methylation with the risk of LSCC in males.
FAU - Shen, Zhisen
AU  - Shen Z
AD  - Department of Otorhinolaryngology, Lihuili Hospital of Ningbo University, Ningbo, 
      Zhejiang 315040, P.R. China.
FAU - Chen, Xiaoying
AU  - Chen X
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Li, Qun
AU  - Li Q
AD  - Department of Otorhinolaryngology, Lihuili Hospital of Ningbo University, Ningbo, 
      Zhejiang 315040, P.R. China; Zhejiang Provincial Key Laboratory of 
      Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, 
      P.R. China.
FAU - Ye, Huadan
AU  - Ye H
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Li, Jinyun
AU  - Li J
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Zhou, Chongchang
AU  - Zhou C
AD  - Department of Otorhinolaryngology, Lihuili Hospital of Ningbo University, Ningbo, 
      Zhejiang 315040, P.R. China; Zhejiang Provincial Key Laboratory of 
      Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, 
      P.R. China.
FAU - Duan, Shiwei
AU  - Duan S
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160816
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5038484
OTO - NOTNLM
OT  - B cell lymphoma 2-like 11
OT  - DNA methylation
OT  - laryngeal cancer, transforming growth factor beta2
OT  - male
EDAT- 2016/10/05 06:00
MHDA- 2016/10/05 06:01
PMCR- 2016/08/16
CRDT- 2016/10/05 06:00
PHST- 2015/05/04 00:00 [received]
PHST- 2016/06/10 00:00 [accepted]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2016/10/05 06:01 [medline]
PHST- 2016/08/16 00:00 [pmc-release]
AID - OL-0-0-5018 [pii]
AID - 10.3892/ol.2016.5018 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Oct;12(4):2999-3003. doi: 10.3892/ol.2016.5018. Epub 2016 Aug 
      16.