PMID- 27698957
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1976-1457 (Print)
IS  - 2005-6168 (Electronic)
IS  - 1976-1457 (Linking)
VI  - 10
IP  - 5
DP  - 2016 Oct
TI  - Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat 
      diets.
PG  - 501-506
AB  - BACKGROUND/OBJECTIVES: Corn silk (CS) extract contains large amounts of maysin, 
      which is a major flavonoid in CS. However, studies regarding the effect of CS 
      extract on cholesterol metabolism is limited. Therefore, the purpose of this 
      study was to determine the effect of CS extract on cholesterol metabolism in 
      C57BL/6J mouse fed high-fat diets. MATERIALS/METHODS: Normal-fat group fed 7% fat 
      diet, high-fat (HF) group fed 25% fat diet, and high-fat with corn silk (HFCS) 
      group were orally administered CS extract (100 mg/kg body weight) daily. Serum 
      and hepatic levels of total lipids, triglycerides, and total cholesterol as well 
      as serum free fatty acid, glucose, and insulin levels were determined. The mRNA 
      expression levels of acyl-CoA: cholesterol acyltransferase (ACAT), cholesterol 
      7-alpha hydroxylase (CYP7A1), farnesoid X receptor (FXR), lecithin cholesterol 
      acyltransferase (LCAT), low-density lipoprotein receptor, 
      3-hyroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), adiponectin, 
      leptin, and tumor necrosis factor alpha were determined. RESULTS: Oral administration 
      of CS extract with HF improved serum glucose and insulin levels as well as 
      attenuated HF-induced fatty liver. CS extracts significantly elevated mRNA 
      expression levels of adipocytokines and reduced mRNA expression levels of HMG-CoA 
      reductase, ACAT, and FXR. The mRNA expression levels of CYP7A1 and LCAT between 
      the HF group and HFCS group were not statistically different. CONCLUSIONS: CS 
      extract supplementation with a high-fat diet improves levels of adipocytokine 
      secretion and glucose homeostasis. CS extract is also effective in decreasing the 
      regulatory pool of hepatic cholesterol, in line with decreased blood and hepatic 
      levels of cholesterol though modulation of mRNA expression levels of HMG-CoA 
      reductase, ACAT, and FXR.
FAU - Cha, Jae Hoon
AU  - Cha JH
AD  - Department of Food Science and Nutrition, Dankook University, 152, Juljeon-ro, 
      Suji-gu, Yonin-si, Gyeonggi 16890, Korea.
FAU - Kim, Sun Rim
AU  - Kim SR
AD  - Agriculture Science Technology, 300 Nongsaengmyeong-ro, Wansan-gu, Jeonju-si, 
      Jeonbuk 54875, Korea.
FAU - Kang, Hyun Joong
AU  - Kang HJ
AD  - Agriculture Science Technology, 300 Nongsaengmyeong-ro, Wansan-gu, Jeonju-si, 
      Jeonbuk 54875, Korea.
FAU - Kim, Myung Hwan
AU  - Kim MH
AD  - Department of Food Engineering, Dankook University, 119, Dandae-ro, Dongnam-gu, 
      Cheonan-si, Chungnam 31116, Korea.
FAU - Ha, Ae Wha
AU  - Ha AW
AD  - Department of Food Science and Nutrition, Dankook University, 152, Juljeon-ro, 
      Suji-gu, Yonin-si, Gyeonggi 16890, Korea.
FAU - Kim, Woo Kyoung
AU  - Kim WK
AD  - Department of Food Science and Nutrition, Dankook University, 152, Juljeon-ro, 
      Suji-gu, Yonin-si, Gyeonggi 16890, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160704
PL  - Korea (South)
TA  - Nutr Res Pract
JT  - Nutrition research and practice
JID - 101311052
PMC - PMC5037067
OTO - NOTNLM
OT  - Corn silk
OT  - adiponectin
OT  - cholesterol
OT  - high-fat
OT  - maysin
COIS- The authors declare no potential conflicts of interests.
EDAT- 2016/10/05 06:00
MHDA- 2016/10/05 06:01
PMCR- 2016/10/01
CRDT- 2016/10/05 06:00
PHST- 2016/04/11 00:00 [received]
PHST- 2016/05/19 00:00 [revised]
PHST- 2016/06/14 00:00 [accepted]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2016/10/05 06:01 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 10.4162/nrp.2016.10.5.501 [doi]
PST - ppublish
SO  - Nutr Res Pract. 2016 Oct;10(5):501-506. doi: 10.4162/nrp.2016.10.5.501. Epub 2016 
      Jul 4.