PMID- 27698971
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2008-5230 (Print)
IS  - 2008-5249 (Electronic)
IS  - 2008-5230 (Linking)
VI  - 8
IP  - 3
DP  - 2016 Jul
TI  - Accuracy of 99mTc (V)-Dimercaptosuccinic Acid Scintigraphy and Fecal Calprotectin 
      Compared with Colonoscopy in Localizing Active Lesions in Inflammatory Bowel 
      Disease.
PG  - 212-218
AB  - INTRODUCTION Due to limitation of colonoscopy in assessing the entire bowel and 
      patients' intolerance in inflammatory bowel disease (IBD), in the current study, 
      we aimed to prospectively compare the accuracy of (99m)Tc(V)-dimercaptosuccinic 
      acid (DMSA) and fecal calprotectin with ileocolonoscopy as new methods for 
      localizing inflammations. METHODS Current prospective study conducted between 
      2012 and 2014 on 30 patients with IBD attending Gastroenterology Clinic of Tehran 
      University of Medical Sciences. Fecal calprotectin and disease activity were 
      measured for all participants and all of them underwent (99m)Tc (V)-DMSA 
      scintigraphy and colonoscopy. The accuracy of (99m)Tc (V)-DMSA scintigraphy and 
      calprotectin in localizing bowel lesions were calculated. RESULTS A total of 22 
      patients with ulcerative colitis (UC) and 8 patients with Crohn's disease (CD) 
      were evaluated in our study. Sensitivity, positive likelihood ratio (PLR), and 
      positive predictive value (PPV) of scintigraphy and calprotectin over colonoscopy 
      in localization of UC lesions were 86.36%, 0.86%, 100.00% and 90.91%, 0.91, and 
      100.00%, respectively. Meanwhile, it showed 66.67% sensitivity and 81.25% 
      specificity with PLR=3.56, negative likelihood ratio (NLR)=0.41, PPV=84.21%, and 
      negative predictive value (NPV)= 61.90% in localizing lesions in patients with 
      CD. The calprotectin level had sensitivity, PLR, and PPV of 90.00%, 0.90, and 
      100.00% in detecting active disease over colonoscopy, respectively. CONCLUSION 
      The (99m)Tc (V)-DMSA scintigraphy would be an accurate method for detecting 
      active inflammation in follow-up of patients with IBD and assessing response to 
      treatment as a non-invasive and complementary method beside colonoscopy for more 
      accurate diagnosis of CD or UC.
FAU - Basirat, Vahid
AU  - Basirat V
AD  - Internal Medicine Resident, Tehran University of Medical Science, Tehran, Iran.
FAU - Azizi, Zahra
AU  - Azizi Z
AD  - Researcher, Iran University of Medical Sciences, Tehran, Iran.
FAU - Javid Anbardan, Sanam
AU  - Javid Anbardan S
AD  - Researcher, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Taghizadeh Asl, Mina
AU  - Taghizadeh Asl M
AD  - Nuclear Medicine Physician, Head of Nuclear Medicine Department, Kasra General 
      Hospital, Tehran, Iran.
FAU - Farbod, Yasaman
AU  - Farbod Y
AD  - Tehran University of Medical Sciences, Tehran, Iran.
FAU - Teimouri, Azam
AU  - Teimouri A
AD  - Fellow of Gastroenterology, Tehran University of medical Sciences, Tehran, Iran.
FAU - Ebrahimi Daryani, Nasser
AU  - Ebrahimi Daryani N
AD  - Professor, Department of Internal Medicine, Division of Gastroenterology, Imam 
      Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Middle East J Dig Dis
JT  - Middle East journal of digestive diseases
JID - 101535395
PMC - PMC5045674
OTO - NOTNLM
OT  - 99mTc (V)-DMSA scintigraphy
OT  - Clinical findings
OT  - Colonoscopy
OT  - Inflammatory bowel disease
EDAT- 2016/10/05 06:00
MHDA- 2016/10/05 06:01
PMCR- 2016/07/01
CRDT- 2016/10/05 06:00
PHST- 2016/10/05 06:00 [entrez]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2016/10/05 06:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - 10.15171/mejdd.2016.23 [doi]
PST - ppublish
SO  - Middle East J Dig Dis. 2016 Jul;8(3):212-218. doi: 10.15171/mejdd.2016.23.