PMID- 27699133
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 7
IP  - 9
DP  - 2016 Sep 1
TI  - Classification of basal cell carcinoma in human skin using machine learning and 
      quantitative features captured by polarization sensitive optical coherence 
      tomography.
PG  - 3721-3735
AB  - We report the first fully automated detection of basal cell carcinoma (BCC), the 
      most commonly occurring type of skin cancer, in human skin using 
      polarization-sensitive optical coherence tomography (PS-OCT). Our proposed 
      automated procedure entails building a machine-learning based classifier by 
      extracting image features from the two complementary image contrasts offered by 
      PS-OCT, intensity and phase retardation (PR), and selecting a subset of features 
      that yields a classifier with the highest accuracy. Our classifier achieved 95.4% 
      sensitivity and specificity, validated by leave-one-patient-out cross validation 
      (LOPOCV), in detecting BCC in human skin samples collected from 42 patients. 
      Moreover, we show the superiority of our classifier over the best possible 
      classifier based on features extracted from intensity-only data, which 
      demonstrates the significance of PR data in detecting BCC.
FAU - Marvdashti, Tahereh
AU  - Marvdashti T
AD  - E. L. Ginzton Laboratory and Department of Electrical Engineering, Stanford 
      University, Stanford, CA 94305, USA.
FAU - Duan, Lian
AU  - Duan L
AD  - E. L. Ginzton Laboratory and Department of Electrical Engineering, Stanford 
      University, Stanford, CA 94305, USA.
FAU - Aasi, Sumaira Z
AU  - Aasi SZ
AD  - Department of Dermatology, Stanford University, Stanford, CA 94305, USA.
FAU - Tang, Jean Y
AU  - Tang JY
AD  - Department of Dermatology, Stanford University, Stanford, CA 94305, USA.
FAU - Ellerbee Bowden, Audrey K
AU  - Ellerbee Bowden AK
AD  - E. L. Ginzton Laboratory and Department of Electrical Engineering, Stanford 
      University, Stanford, CA 94305, USA.
LA  - eng
PT  - Journal Article
DEP - 20160829
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC5030045
OTO - NOTNLM
OT  - (100.0100) Image processing
OT  - (110.4500) Optical coherence tomography
OT  - (170.1870) Dermatology
OT  - (170.3880) Medical and biological imaging
OT  - (230.5440) Polarization-selective devices
EDAT- 2016/10/05 06:00
MHDA- 2016/10/05 06:01
PMCR- 2016/08/29
CRDT- 2016/10/05 06:00
PHST- 2016/06/24 00:00 [received]
PHST- 2016/08/07 00:00 [revised]
PHST- 2016/08/08 00:00 [accepted]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2016/10/05 06:01 [medline]
PHST- 2016/08/29 00:00 [pmc-release]
AID - 267313 [pii]
AID - 10.1364/BOE.7.003721 [doi]
PST - epublish
SO  - Biomed Opt Express. 2016 Aug 29;7(9):3721-3735. doi: 10.1364/BOE.7.003721. 
      eCollection 2016 Sep 1.