PMID- 27699959
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20180716
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 22
IP  - 6
DP  - 2017 Nov
TI  - Gender differences in the inflammatory cytokine and chemokine profiles induced by 
      binge ethanol drinking in adolescence.
PG  - 1829-1841
LID - 10.1111/adb.12461 [doi]
AB  - Heavy binge drinking in adolescence can cause long-term cognitive and behavioral 
      dysfunctions. Recent experimental evidence indicates the participation of immune 
      system activation in the effects of ethanol in the adolescent brain and suggests 
      gender differences. The present study aims to assess plasma cytokine and 
      chemokine levels in male and female adolescents and young adults during acute 
      alcohol intoxication and to correlate these results with the toll-like receptor 4 
      (TLR4) response. The potential role of the TLR4 signaling response was also 
      assessed in plasma and prefrontal cortex (PFC) of adolescent wild-type and 
      TLR4-knockout male and female mice with binge ethanol treatment. The results 
      showed that alcohol intoxication increased the plasma levels of several cytokine 
      and chemokine [interferon-gamma, interleukin (IL)-10, IL-17A, IL-1beta, IL-2, IL-4, 
      IL-6, IL-8, fractalkine, monocyte chemoattractant protein 1 (MCP-1) and 
      macrophage inflammatory protein 1alpha (MIP-1alpha)] and the upregulation of TLR4 mRNA 
      levels occurred in intoxicated females, while elevation of colony-stimulating 
      factor was only observed in the plasma of males. In wild-type female adolescent 
      mice, intermittent ethanol treatment increased the levels of several cytokines 
      (IL-17A and IL-1beta) and chemokines (MCP-1, MIP-1alpha and fractalkine) in PFC and in 
      serum (IL-17A, MCP-1 and MIP-1alpha), but significant differences in the fractalkine 
      levels in PFC were observed only in male mice. No changes in serum or prefrontal 
      cortex cytokine and chemokine levels were noted in ethanol-treated male or female 
      TLR4-knockout mice. Our findings revealed that females are more vulnerable than 
      males to inflammatory effects of binge ethanol drinking and suggested that TLR4 
      is an important target of ethanol-induced inflammation and neuroinflammation in 
      adolescence.
CI  - (c) 2016 Society for the Study of Addiction.
FAU - Pascual, Maria
AU  - Pascual M
AD  - Department of Molecular and Cellular Pathology of Alcohol, Principe Felipe 
      Research Center, Spain.
FAU - Montesinos, Jorge
AU  - Montesinos J
AD  - Department of Molecular and Cellular Pathology of Alcohol, Principe Felipe 
      Research Center, Spain.
FAU - Marcos, Miguel
AU  - Marcos M
AD  - Alcoholism Unit, Department of Internal Medicine, University Hospital of 
      Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), Spain.
FAU - Torres, Jorge-Luis
AU  - Torres JL
AD  - Alcoholism Unit, Department of Internal Medicine, University Hospital of 
      Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), Spain.
FAU - Costa-Alba, Pilar
AU  - Costa-Alba P
AD  - Emergency Department, University Hospital of Salamanca-IBSAL, Spain.
FAU - Garcia-Garcia, Francisco
AU  - Garcia-Garcia F
AD  - Computational Genomics Department, Principe Felipe Research Center, Spain.
FAU - Laso, Francisco-Javier
AU  - Laso FJ
AD  - Alcoholism Unit, Department of Internal Medicine, University Hospital of 
      Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), Spain.
FAU - Guerri, Consuelo
AU  - Guerri C
AD  - Department of Molecular and Cellular Pathology of Alcohol, Principe Felipe 
      Research Center, Spain.
LA  - eng
PT  - Journal Article
DEP - 20161004
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Binge Drinking/*blood/metabolism
MH  - Brain/drug effects/metabolism
MH  - Central Nervous System Depressants/blood/*pharmacology
MH  - Chemokines/blood/metabolism
MH  - Cytokines/*blood/metabolism
MH  - Disease Models, Animal
MH  - Ethanol/blood/*pharmacology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Polymerase Chain Reaction
MH  - Sex Factors
MH  - Spain
MH  - *Underage Drinking
MH  - Young Adult
OTO - NOTNLM
OT  - Adolescent humans
OT  - TLR4
OT  - adolescent mice
OT  - gender difference
OT  - inflammation
EDAT- 2016/10/05 06:00
MHDA- 2018/07/17 06:00
CRDT- 2016/10/05 06:00
PHST- 2016/03/21 00:00 [received]
PHST- 2016/08/03 00:00 [revised]
PHST- 2016/09/09 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
AID - 10.1111/adb.12461 [doi]
PST - ppublish
SO  - Addict Biol. 2017 Nov;22(6):1829-1841. doi: 10.1111/adb.12461. Epub 2016 Oct 4.