PMID- 27702516
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180208
LR  - 20180208
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 155
DP  - 2017 Jan 2
TI  - Radiation grafting of N-vinylcaprolactam onto nano and macrogels of chitosan: 
      Synthesis and characterization.
PG  - 303-312
LID - S0144-8617(16)31035-9 [pii]
LID - 10.1016/j.carbpol.2016.08.083 [doi]
AB  - The aim of this study was to synthesize chitosan hydrogels, in macro- and 
      nano-size, grafted with N-vinylcaprolactam (NVCL) using gamma radiation, and 
      evaluate their potential application as a drug delivery system, using 
      5-fluorouracil (5-FU) as a model drug. The effect of dose and monomer 
      concentration in the grafting process was studied, and the materials were 
      characterized by FTIR, TGA, DLS, SEM and AFM. Higher grafting percentages were 
      observed for the nanogels system. Although both the grafted macro- and nanogels, 
      (net-CS)-g-NVCL, showed a response to pH (4.75) and temperature (31-33 degrees C), the 
      nanogels showed a better swelling response to both stimuli because of their 
      higher surface area. Both systems were able to load 5-FU in small amounts 
      (2-3.5mgg(-1)) and the release was sustained for more than 12h, showing that the 
      modified macro and nanogels can be a potential alternative for the administration 
      of drugs.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Cruz, Angelica
AU  - Cruz A
AD  - Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Ciudad 
      Universitaria, Mexico 04510, D.F., Mexico.
FAU - Garcia-Uriostegui, Lorena
AU  - Garcia-Uriostegui L
AD  - CONACYT Research Fellow at Departamento de Madera Celulosa y Papel-Universidad de 
      Guadalajara, Carretera Guadalajara-Nogales Km. 15.5, Zapopan, Jalisco 45110, 
      Mexico.
FAU - Ortega, Alejandra
AU  - Ortega A
AD  - Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Ciudad 
      Universitaria, Mexico 04510, D.F., Mexico.
FAU - Isoshima, Takashi
AU  - Isoshima T
AD  - Nano Medical Engineering Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, 
      Japan.
FAU - Burillo, Guillermina
AU  - Burillo G
AD  - Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Ciudad 
      Universitaria, Mexico 04510, D.F., Mexico. Electronic address: 
      burillo@nucleares.unam.mx.
LA  - eng
PT  - Journal Article
DEP - 20160829
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
OTO - NOTNLM
OT  - Chitosan grafting
OT  - N-vinylcaprolactam
OT  - Nanogels of chitosan
OT  - Radiation grafting
EDAT- 2016/10/06 06:00
MHDA- 2016/10/06 06:01
CRDT- 2016/10/06 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2016/08/24 00:00 [revised]
PHST- 2016/08/26 00:00 [accepted]
PHST- 2016/10/06 06:00 [entrez]
PHST- 2016/10/06 06:00 [pubmed]
PHST- 2016/10/06 06:01 [medline]
AID - S0144-8617(16)31035-9 [pii]
AID - 10.1016/j.carbpol.2016.08.083 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 Jan 2;155:303-312. doi: 10.1016/j.carbpol.2016.08.083. Epub 
      2016 Aug 29.