PMID- 27703287
OWN - NLM
STAT- MEDLINE
DCOM- 20180302
LR  - 20181113
IS  - 0350-199X (Print)
IS  - 1986-5961 (Electronic)
IS  - 0350-199X (Linking)
VI  - 70
IP  - 4
DP  - 2016 Jul 27
TI  - A Comparison of Prognostic Value of the Levels of ProBNP and Troponin T in 
      Patients with Acute Coronary Syndrome (ACS).
PG  - 269-273
AB  - INTRODUCTION: The propeptide of brain natriuretic peptide (ProBNP) is used for 
      the diagnosis of left ventricle dysfunction and heart failure. In patients with 
      an Acute Coronary Syndrome (ACS) it can contribute to both short and long term 
      prognosis of cardiovascular events that could be very important for management 
      and therapy of these patients. AIM: The aim of this study was to evaluate the 
      prognostic value of ProBNP for the clinical course after an acute coronary 
      syndrome, compared with that of cardiac troponine T (cTnT) and the risk 
      stratification of patients with acute coronary syndrome, both during 
      hospitalization and six months later. METHODS: We studied 390 patients (256 men, 
      134 women, mean age 66.04+12.38) with an acute coronary syndrome who were 
      hospitalized in the Coronary Unit of our cardiology clinic. We studied 
      epidemiological and clinical data and biochemical markers were examined as 
      prognostic factors for clinical course intrahospital and during six months 
      follow-up. RESULTS: In the majority of patients, a myocardial infarction without 
      ST elevation was diagnosed (NSTEMI) (193 patients 49.49%) while 167 patients 
      (42.82%) had a myocardial infarction with ST elevation (STEMI) and the remaining 
      30 patients (7.69%) had unstable angina. Patients had multiple risk factors for 
      coronary heart disease. The levels of ProBNP were significantly elevated in 
      patients with STEMI (p=0.003) and NSTEMI (p=0.002) who died or experienced an 
      adverse event (angina, myocardial infarction, cardiogenic shock, congestive heart 
      failure, arrhythmias) during hospitalization. After six months of follow-up, 
      patients who had an adverse event had higher levels of ProBNP. There was no 
      difference in troponine T levels in patients with STEMI and NSTEMI who had 
      adverse events compared with the others, either during hospitalization or after 
      six months. CONCLUSION: The level of ProBNP is an important predictor of 
      cardiovascular events in patients with acute coronary syndrome. This study showed 
      that it provides better predictive power than the troponine T.
FAU - Vogiatzis, Ioannis
AU  - Vogiatzis I
AD  - Department of Cardiology, General Hospital of Veroia, Greece.
FAU - Dapcevic, Irena
AU  - Dapcevic I
AD  - Department of Cardiology, General Hospital of Veroia, Greece.
FAU - Datsios, Antonis
AU  - Datsios A
AD  - Department of Cardiology, General Hospital of Veroia, Greece.
FAU - Koutsambasopoulos, Kostas
AU  - Koutsambasopoulos K
AD  - Department of Cardiology, General Hospital of Veroia, Greece.
FAU - Gontopoulos, Argirios
AU  - Gontopoulos A
AD  - Department of Cardiology, General Hospital of Veroia, Greece.
FAU - Grigoriadis, Savas
AU  - Grigoriadis S
AD  - Department of Cardiology, General Hospital of Veroia, Greece.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Med Arch
JT  - Medical archives (Sarajevo, Bosnia and Herzegovina)
JID - 101635337
RN  - 0 (Troponin T)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Acute Coronary Syndrome/*blood/diagnosis/mortality
MH  - Aged
MH  - Angina, Unstable/blood/diagnosis/etiology
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/diagnosis/etiology
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Troponin T/*blood
PMC - PMC5034970
OTO - NOTNLM
OT  - NONSTEMI
OT  - ProBNP
OT  - STEMI
OT  - troponin T
COIS- * Conflicts of interest: nothing to declare.
EDAT- 2016/10/06 06:00
MHDA- 2018/03/03 06:00
PMCR- 2016/07/27
CRDT- 2016/10/06 06:00
PHST- 2016/05/25 00:00 [received]
PHST- 2016/07/05 00:00 [accepted]
PHST- 2016/10/06 06:00 [entrez]
PHST- 2016/10/06 06:00 [pubmed]
PHST- 2018/03/03 06:00 [medline]
PHST- 2016/07/27 00:00 [pmc-release]
AID - MA-70-269 [pii]
AID - 10.5455/medarh.2016.70.269-273 [doi]
PST - ppublish
SO  - Med Arch. 2016 Jul 27;70(4):269-273. doi: 10.5455/medarh.2016.70.269-273.