PMID- 27703408 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1340-3516 (Print) IS - 1347-7501 (Electronic) IS - 1340-3516 (Linking) VI - 27 IP - 3 DP - 2016 TI - Reference range of blood biomarkers for oxidative stress in Thoroughbred racehorses (2-5 years old). PG - 125-129 AB - The oxidant and antioxidant equilibrium is known to play an important role in equine medicine and equine exercise physiology. There are abundant findings in this field; however, not many studies have been conducted for reference ranges of oxidative stress biomarkers in horses. This study was conducted to determine the reference values of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) using blood samples from 372 (191 males, 181 females) Thoroughbred racehorse aged 2 to 5 (3.43 +/- 1.10 (mean +/- SD)) years old. There were obvious gender differences in oxidative biomarkers, and growth/age-related changes were observed especially in females. Gender and age must be considered when interpreting obtained oxidative stress biomarkers for diagnosis of disease or fitness alterations in Thoroughbred racehorses. FAU - Kusano, Kanichi AU - Kusano K AD - Miho Training Center, Racehorse Hospital, Japan Racing Association, Ibaraki 300-0493, Japan. FAU - Yamazaki, Masahiko AU - Yamazaki M AD - Yamazaki Horse Clinic, Ibaraki 300-0415, Japan. FAU - Kiuchi, Masataka AU - Kiuchi M AD - Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 400-8510, Japan. FAU - Kaneko, Kouki AU - Kaneko K AD - Wismerll Company Limited, Tokyo 113-0033, Japan. FAU - Koyama, Katsuhiro AU - Koyama K AD - Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi 400-8510, Japan. LA - eng PT - Journal Article DEP - 20160930 PL - Japan TA - J Equine Sci JT - Journal of equine science JID - 9503751 PMC - PMC5048360 OTO - NOTNLM OT - Thoroughbred racehorse OT - oxidative stress biomarker OT - reference range EDAT- 2016/10/06 06:00 MHDA- 2016/10/06 06:01 PMCR- 2016/01/01 CRDT- 2016/10/06 06:00 PHST- 2016/03/22 00:00 [received] PHST- 2016/06/10 00:00 [accepted] PHST- 2016/10/06 06:00 [entrez] PHST- 2016/10/06 06:00 [pubmed] PHST- 2016/10/06 06:01 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - 1606 [pii] AID - 10.1294/jes.27.125 [doi] PST - ppublish SO - J Equine Sci. 2016;27(3):125-129. doi: 10.1294/jes.27.125. Epub 2016 Sep 30.