PMID- 27704740
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2093-596X (Print)
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Linking)
VI  - 31
IP  - 3
DP  - 2016 Sep
TI  - Correlation of Glypican-4 Level with Basal Active Glucagon-Like Peptide 1 Level 
      in Patients with Type 2 Diabetes Mellitus.
PG  - 439-445
LID - 10.3803/EnM.2016.31.3.439 [doi]
AB  - BACKGROUND: Previous studies have reported that glypican-4 (GPC4) regulates 
      insulin signaling by interacting with insulin receptor and through adipocyte 
      differentiation. However, GPC4 has not been studied with regard to its effects on 
      clinical factors in patients with type 2 diabetes mellitus (T2DM). We aimed to 
      identify factors associated with GPC4 level in T2DM. METHODS: Between January 
      2010 and December 2013, we selected 152 subjects with T2DM and collected serum 
      and plasma into tubes pretreated with aprotinin and dipeptidyl peptidase-4 
      inhibitor to preserve active gastric inhibitory polypeptide (GIP) and 
      glucagon-like peptide 1 (GLP-1). GPC4, active GLP-1, active GIP, and other 
      factors were measured in these plasma samples. We performed a linear regression 
      analysis to identify factors associated with GPC4 level. RESULTS: The subjects 
      had a mean age of 58.1 years, were mildly obese (mean body mass index [BMI], 26.1 
      kg/m(2)), had T2DM of long-duration (mean, 101.3 months), glycated hemoglobin 7.5%, 
      low insulin secretion, and low insulin resistance (mean homeostatic model 
      assessment of insulin resistance [HOMA-IR], 1.2). Their mean GPC4 was 2.0+/-0.2 
      ng/mL. In multivariate analysis, GPC4 was independently associated with age 
      (beta=0.224, P=0.009), and levels of active GLP-1 (beta=0.171, P=0.049) and aspartate 
      aminotransferase (AST; beta=-0.176, P=0.043) after being adjusted for other clinical 
      factors. CONCLUSION: GPC4 was independently associated with age, active GLP-1, 
      and AST in T2DM patients, but was not associated with HOMA-IR and BMI, which are 
      well known factors related to GPC4. Further study is needed to identify the 
      mechanisms of the association between GPC4 and basal active GLP-1 levels.
FAU - Lee, Sang Ah
AU  - Lee SA
AUID- ORCID: 0000-0002-9797-8050
AD  - Department of Internal Medicine, Jeju National University School of Medicine, 
      Jeju, Korea. salee@jejunu.ac.kr.
FAU - Koh, Gwanpyo
AU  - Koh G
AD  - Department of Internal Medicine, Jeju National University School of Medicine, 
      Jeju, Korea.
FAU - Cho, Suk Ju
AU  - Cho SJ
AD  - Department of Anesthesiology, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Yoo, So Yeon
AU  - Yoo SY
AD  - Department of Internal Medicine, Jeju National University School of Medicine, 
      Jeju, Korea.
FAU - Chin, Sang Ouk
AU  - Chin SO
AD  - Department of Internal Medicine, Jeju National University School of Medicine, 
      Jeju, Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
PMC - PMC5053057
OTO - NOTNLM
OT  - Active glucagon-like peptide 1
OT  - Diabetes mellitus
OT  - Glypicans
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/10/06 06:00
MHDA- 2016/10/06 06:01
PMCR- 2016/09/01
CRDT- 2016/10/06 06:00
PHST- 2016/04/20 00:00 [received]
PHST- 2016/06/17 00:00 [revised]
PHST- 2016/07/04 00:00 [accepted]
PHST- 2016/10/06 06:00 [entrez]
PHST- 2016/10/06 06:00 [pubmed]
PHST- 2016/10/06 06:01 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 31.439 [pii]
AID - 10.3803/EnM.2016.31.3.439 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2016 Sep;31(3):439-445. doi: 10.3803/EnM.2016.31.3.439.