PMID- 27706609
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20170224
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 15
IP  - 3
DP  - 2016 Aug 26
TI  - Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 
      2 diabetes mellitus: a meta-analysis.
LID - 10.4238/gmr.15037969 [doi]
AB  - Increasing evidence has demonstrated that a transcription factor 7-like 2 
      (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 
      diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity 
      in the studies investigating this association have led to conflicting reports 
      regarding its role. Therefore, a comprehensive meta-analysis was conducted to 
      quantitatively assess the association between the TCF7L2 polymorphism (rs7903146) 
      and T2DM including published case-control studies in global populations. We 
      searched the PubMed, EMbase, CNKI, and Wanfang databases for publications that 
      studied correlation between TCF7L2 polymorphism (rs7903146) and risk of T2DM. 
      Thirty-six studies from 30 eligible papers were identified. After data extraction 
      and reference quality assessment, summary odds ratio and 95% confidence intervals 
      (95%CI) of the TCF7L2 (rs7903146) polymorphism were calculated and combined using 
      the fixed-effect model. Hardy-Weinberg equilibrium was evaluated to determine 
      selection bias of the control subjects. Heterogeneity among studies was examined 
      using the Q-test and the I(2) test. Publication bias in studies was assessed 
      using Begg's plots and the Egger test. The results showed that the rs7903146 T 
      allele of the TCF7L2 gene was positively correlated with an enhanced risk of T2DM 
      in the allelic, heterozygote, homozygote, dominant, and recessive models, with 
      odds ratios of 1.35 (T vs C, 95%CI = 1.31-1.39), 1.32 (CT vs CC, 95%CI = 
      1.27-1.38), 1.74 (TT vs CC, 95%CI = 1.63-1.87), 1.40 (TT+CT vs CC, 95%CI = 
      1.35-1.46), and 1.59 (TT vs CT+CC, 95%CI = 1.49-1.69), respectively. No obvious 
      publication bias was observed using the Egger linear test.
FAU - Guan, Y
AU  - Guan Y
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Yan, L H
AU  - Yan LH
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Liu, X Y
AU  - Liu XY
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Zhu, X Y
AU  - Zhu XY
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Wang, S Z
AU  - Wang SZ
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Chen, L M
AU  - Chen LM
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China 
      chenlmingtj@yeah.net.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160826
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics/pathology
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Models, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - Transcription Factor 7-Like 2 Protein/*genetics
COIS- The authors declare no conflict of interest.
EDAT- 2016/10/06 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/10/06 06:00
PHST- 2016/10/06 06:00 [entrez]
PHST- 2016/10/06 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - gmr7969 [pii]
AID - 10.4238/gmr.15037969 [doi]
PST - epublish
SO  - Genet Mol Res. 2016 Aug 26;15(3). doi: 10.4238/gmr.15037969.