PMID- 27706615
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20170224
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 15
IP  - 3
DP  - 2016 Aug 26
TI  - HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis.
LID - 10.4238/gmr.15038263 [doi]
AB  - Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in 
      the placenta and is crucial for implantation of the embryo and immunological 
      tolerance of the fetus during pregnancy. However, under pathological conditions, 
      such as cancer or viral infections, HLA-G can be expressed in other tissues. The 
      gene coding for HLA-G (HLA-G, chromosome 6p21.3) presents numerous polymorphisms, 
      some of them influencing its expression. One of the most studied, is the 14 bp 
      ins/del (rs371194629) situated at the 3'-UTR of the gene. The insertion is 
      thought to stabilize HLA-G mRNA. Different studies have analyzed the role of 
      rs371194629 in hepatic injury, with either hepatotropic virus infection (i.e., 
      HBV or HCV) or hepatocellular carcinoma (also induced by viral infection). 
      Results from these studies are heterogeneous, differing with ethnicity and 
      population age, and the role of rs371194629 is unclear. For these reasons, we 
      decided to perform a meta-analysis of these results, concluding that the 14-bp 
      ins/del polymorphism does not significantly contribute to hepatic injury.
FAU - Coelho, A V C
AU  - Coelho AV
AD  - Departamento de Genetica, Universidade Federal de Pernambuco, Recife, PE, Brasil 
      antonio.victor@ufpe.br.
FAU - Moura, R R
AU  - Moura RR
AD  - Departamento de Genetica, Universidade Federal de Pernambuco, Recife, PE, Brasil.
FAU - Crovella, S
AU  - Crovella S
AD  - Departamento de Genetica, Universidade Federal de Pernambuco, Recife, PE, Brasil.
FAU - Celsi, F
AU  - Celsi F
AD  - Institute for Maternal and Child Health, Scientific Institute for Research, 
      Hospitalization and Care Burlo Garofolo, Trieste, Italia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160826
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Adult
MH  - Carcinoma, Hepatocellular/*genetics/immunology/pathology
MH  - Case-Control Studies
MH  - Gene Expression
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-G Antigens/*genetics/immunology
MH  - Humans
MH  - *INDEL Mutation
MH  - Liver/immunology/pathology
MH  - Liver Neoplasms/*genetics/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
COIS- The authors declare no conflict of interest.
EDAT- 2016/10/06 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/10/06 06:00
PHST- 2016/10/06 06:00 [entrez]
PHST- 2016/10/06 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - gmr8263 [pii]
AID - 10.4238/gmr.15038263 [doi]
PST - epublish
SO  - Genet Mol Res. 2016 Aug 26;15(3). doi: 10.4238/gmr.15038263.