PMID- 27708856 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210109 IS - 2055-5822 (Print) IS - 2055-5822 (Electronic) IS - 2055-5822 (Linking) VI - 2 IP - 3 DP - 2015 Sep TI - Validation of the FEW16 questionnaire for the assessment of physical well-being in patients with heart failure with reduced ejection fraction: results from the CIBIS-ELD study. PG - 194-203 AB - AIMS: Patients with heart failure (HF) commonly suffer from severe impairment of quality of life (QoL). One main goal of HF treatment is improvement of QoL. Physical well-being is an essential component of QoL. To enable assessment of physical well-being in HF patients, we validated the FEW16 questionnaire in a prospective study with patients from the Cardiac Insufficiency Bisoprolol Study in ELDerly. METHODS AND RESULTS: In 127 HF patients (age 73 +/- 5.5 years, 72% male, 60% New York Heart Association class II, left ventricular ejection fraction 37 +/- 8.5%), we measured physical well-being (FEW16), QoL [36-Item Short-Form Health Survey (SF36)], and depressive symptoms [PRIME MD Patient Health Questionnaire German short version for depression (PHQ-D)] at baseline and two follow-up visits, and correlated FEW16 scores with QoL data and clinical parameters. FEW16 mean scores are 3.04 +/- 1.04 at baseline, 3.19 +/- 0.94 after 3 months, and 2.77 +/- 0.94 after 2-4 years. We assessed data quality, scale assumptions, and construct validity and reliability. Cronbach's alpha for subscales resilience: 0.84; ability to enjoy: 0.80; vitality: 0.88; inner peace: 0.87; total score: 0.95. Intraclass correlation coefficient (ICC) is 0.87 (95% CI 0.84-0.89, ICC (1.4). Pearson's correlations of FEW16 with SF36 and PHQ-D were significant. Six minutes walking distance and heart rate correlated significantly with the FEW16 total score. CONCLUSIONS: The FEW16 showed good reliability, internal consistency, and intraclass correlation. FEW16 scores correlated well with psychological and physical well-being (SF36) and clinical markers of exercise tolerance (6 min walk test and heart rate). Our results indicate a strong correlation of self-reported physical well-being with psychological factors. FEW16 values at baseline predicted the development of several aspects of QoL during beta-blocker up-titration. FAU - Tahirovic, E AU - Tahirovic E AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Lashki, D J AU - Lashki DJ AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Trippel, T D AU - Trippel TD AD - Department of Internal Medicine - CardiologyCharite University Medicine BerlinGermany; German Center for Cardiovascular Research (DZHK)Site BerlinGermany. FAU - Tscholl, V AU - Tscholl V AD - Medical Clinic for Cardiology and Pulmonology, Campus Benjamin Franklin Charite University Medicine Berlin Germany. FAU - Fritschka, M AU - Fritschka M AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Musial-Bright, L AU - Musial-Bright L AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Busjahn, A AU - Busjahn A AD - HealthTwiSt GmbH Berlin Germany. FAU - Kolip, P AU - Kolip P AD - Department of Prevention and Health Promotion, School of Public Health Bielefeld University Bielefeld Germany. FAU - Stork, S AU - Stork S AD - Comprehensive Heart Failure Center University of Wurzburg Germany. FAU - Rauchfuss, M AU - Rauchfuss M AD - Centre of Internal Medicine and Dermatology, Clinic for Internal Medicine and Psychosomatics Charite University Medicine Berlin Germany. FAU - Inkrot, S AU - Inkrot S AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Lainscak, M AU - Lainscak M AD - Department of Cardiology and Department of Research and EducationGeneral Hospital Celje, Slovenia and Faculty of Medicine, University of LjubljanaCeljeSlovenia; Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia. FAU - Apostolovic, S AU - Apostolovic S AD - Clinical Center Nis, Department of Internal Medicine University of Nis Serbia. FAU - Veskovic, J AU - Veskovic J AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Loncar, G AU - Loncar G AD - Cardiology Department Zvezdara University Medical Center Belgrade Serbia. FAU - Doehner, W AU - Doehner W AD - Center for Stroke Research Charite University Medicine Berlin Germany. FAU - Zelenak, C AU - Zelenak C AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. FAU - Dungen, H D AU - Dungen HD AD - Department of Internal Medicine - Cardiology Charite University Medicine Berlin Germany. LA - eng PT - Journal Article DEP - 20150720 PL - England TA - ESC Heart Fail JT - ESC heart failure JID - 101669191 PMC - PMC5034814 OTO - NOTNLM OT - FEW16 OT - Heart failure OT - Physical well-being OT - Quality of life (QoL) OT - Validation COIS- H.-D.D. reported receiving research grant support and travel support from Merck KGaA and equipment provision support from Merck KgaA, Roche, and Biosite. E.T. reported receiving support from Merck KGaA, Getemed AG, and ResMed. For all other authors, there is nothing to declare. EDAT- 2016/10/07 06:00 MHDA- 2016/10/07 06:01 PMCR- 2015/07/20 CRDT- 2016/10/07 06:00 PHST- 2015/01/26 00:00 [received] PHST- 2015/05/07 00:00 [revised] PHST- 2015/05/19 00:00 [accepted] PHST- 2016/10/07 06:00 [entrez] PHST- 2016/10/07 06:00 [pubmed] PHST- 2016/10/07 06:01 [medline] PHST- 2015/07/20 00:00 [pmc-release] AID - EHF212045 [pii] AID - 10.1002/ehf2.12045 [doi] PST - ppublish SO - ESC Heart Fail. 2015 Sep;2(3):194-203. doi: 10.1002/ehf2.12045. Epub 2015 Jul 20.