PMID- 27708934
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2147-9720 (Print)
IS  - 2148-4279 (Electronic)
IS  - 2147-9720 (Linking)
VI  - 2
IP  - 2
DP  - 2015 Jun
TI  - High-dose intravenous immunoglobulin therapy for rapidly progressive interstitial 
      pneumonitis accompanied by anti-melanoma differentiation-associated gene 5 
      antibody-positive amyopathic dermatomyositis.
PG  - 83-85
AB  - Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive 
      amyopathic dermatomyositis (ADM) associated with rapidly progressive interstitial 
      pneumonitis (RPIP) frequently has a poor prognosis and optimal treatment is not 
      well defined. Here, we report a 62-year-old Japanese man with anti-MDA5 
      antibody-positive ADM associated with RPIP presented with progressive shortness 
      of breath, Heliotrope rash, Gottron's papules, arthralgia, and fatigue but no 
      sign of muscle weakness. Laboratory investigation revealed serum levels of the 
      following biomarkers: ferritin, 1393 ng/mL; Krebs von der Lungen-6, 1880 U/mL; 
      and creatine kinase, 85 U/L. Computed tomography (CT) images showed diffuse 
      ground-glass opacity in both lung fields. Because anti-MDA5 was positive, we made 
      a diagnosis of ADM associated with RPIP and initiated treatment. Following five 
      courses of combination therapy with prednisolone, cyclosporine A, and intravenous 
      cyclophosphamide (IVCY), IVCY treatment was switched to high-dose intravenous 
      immunoglobulin therapy (IVIg) because of the reactivation of interstitial 
      pneumonia with an increased serum ferritin level. Additional treatment with IVIg 
      improved RPIP, with normalization of anti-ADM antibody levels. Therefore, IVIg 
      mayt be a new candidate treatment for anti-MDA5 antibody-positive ADM associated 
      with RPIP.
FAU - Hamada-Ode, Kazu
AU  - Hamada-Ode K
AD  - Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi 
      University Medical School, Kochi, Japan.
FAU - Taniguchi, Yoshinori
AU  - Taniguchi Y
AD  - Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi 
      University Medical School, Kochi, Japan.
FAU - Kimata, Takahito
AU  - Kimata T
AD  - Department of Rheumatology, Misato Bay Side Medical Center, Kochi, Japan.
FAU - Kawaguchi, Yasushi
AU  - Kawaguchi Y
AD  - Department of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Shimamura, Yoshiko
AU  - Shimamura Y
AD  - Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi 
      University Medical School, Kochi, Japan.
FAU - Kuwana, Masataka
AU  - Kuwana M
AD  - Department of Rheumatology, Nippon Medical School, Tokyo, Japan.
FAU - Fujimoto, Shimpei
AU  - Fujimoto S
AD  - Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi 
      University Medical School, Kochi, Japan.
FAU - Terada, Yoshio
AU  - Terada Y
AD  - Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi 
      University Medical School, Kochi, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150331
PL  - Turkey
TA  - Eur J Rheumatol
JT  - European journal of rheumatology
JID - 101656068
PMC - PMC5047270
OTO - NOTNLM
OT  - Amyopathic
OT  - anti-MDA5 antibody
OT  - dermatomyositis
OT  - interstitial pneumonitis
EDAT- 2015/06/01 00:00
MHDA- 2015/06/01 00:01
PMCR- 2015/06/01
CRDT- 2016/10/07 06:00
PHST- 2014/08/09 00:00 [received]
PHST- 2014/10/10 00:00 [accepted]
PHST- 2016/10/07 06:00 [entrez]
PHST- 2015/06/01 00:00 [pubmed]
PHST- 2015/06/01 00:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - ejr-2-2-83 [pii]
AID - 10.5152/eurjrheum.2015.0076 [doi]
PST - ppublish
SO  - Eur J Rheumatol. 2015 Jun;2(2):83-85. doi: 10.5152/eurjrheum.2015.0076. Epub 2015 
      Mar 31.