PMID- 27709426
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20181113
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 32
IP  - 1
DP  - 2017 Feb
TI  - Diet, gut microbiota and cognition.
PG  - 1-17
LID - 10.1007/s11011-016-9917-8 [doi]
AB  - The consumption of a diet high in fat and sugar can lead to the development of 
      obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease and cognitive 
      decline. In the human gut, the trillions of harmless microorganisms harboured in 
      the host's gastrointestinal tract are called the 'gut microbiota'. Consumption of 
      a diet high in fat and sugar changes the healthy microbiota composition which 
      leads to an imbalanced microbial population in the gut, a phenomenon known as 
      "gut dysbiosis". It has been shown that certain types of gut microbiota are 
      linked to the pathogenesis of obesity. In addition, long-term consumption of a 
      high fat diet is associated with cognitive decline. It has recently been proposed 
      that the gut microbiota is part of a mechanistic link between the consumption of 
      a high fat diet and the impaired cognition of an individual, termed 
      "microbiota-gut-brain axis". In this complex relationship between the gut, the 
      brain and the gut microbiota, there are several types of gut microbiota and host 
      mechanisms involved. Most of these mechanisms are still poorly understood. 
      Therefore, this review comprehensively summarizes the current evidence from 
      mainly in vivo (rodent and human) studies of the relationship between diet, gut 
      microbiota and cognition. The possible mechanisms that the diet and the gut 
      microbiota have on cognition are also presented and discussed.
FAU - Proctor, Cicely
AU  - Proctor C
AD  - Faculty of Life Sciences, The University of Manchester, Manchester, UK.
AD  - Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, 
      Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
AD  - Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai 
      University, Chiang Mai, Thailand.
FAU - Thiennimitr, Parameth
AU  - Thiennimitr P
AD  - Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang 
      Mai, Thailand.
FAU - Chattipakorn, Nipon
AU  - Chattipakorn N
AD  - Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, 
      Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
AD  - Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai 
      University, Chiang Mai, Thailand.
FAU - Chattipakorn, Siriporn C
AU  - Chattipakorn SC
AD  - Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, 
      Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. 
      scchattipakorn@gmail.com.
AD  - Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand. scchattipakorn@gmail.com.
AD  - Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang 
      Mai University, Chiang Mai, 50200, Thailand. scchattipakorn@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161005
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
SB  - IM
MH  - Cognition/*physiology
MH  - Diabetes Mellitus, Type 2/*microbiology/psychology
MH  - *Diet
MH  - Gastrointestinal Microbiome/*physiology
MH  - Gastrointestinal Tract/*microbiology
MH  - Humans
MH  - Obesity/*microbiology/psychology
OTO - NOTNLM
OT  - A high fat/high sugar diet
OT  - Cognition
OT  - Gut microbiota
OT  - Obesity
EDAT- 2016/10/07 06:00
MHDA- 2018/02/01 06:00
CRDT- 2016/10/07 06:00
PHST- 2016/03/17 00:00 [received]
PHST- 2016/09/23 00:00 [accepted]
PHST- 2016/10/07 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
PHST- 2016/10/07 06:00 [entrez]
AID - 10.1007/s11011-016-9917-8 [pii]
AID - 10.1007/s11011-016-9917-8 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2017 Feb;32(1):1-17. doi: 10.1007/s11011-016-9917-8. Epub 2016 
      Oct 5.