PMID- 27712587
OWN - NLM
STAT- MEDLINE
DCOM- 20170405
LR  - 20220321
IS  - 1555-3906 (Electronic)
IS  - 0965-0407 (Print)
IS  - 0965-0407 (Linking)
VI  - 24
IP  - 5
DP  - 2016
TI  - TIPE2 Overexpression Suppresses the Proliferation, Migration, and Invasion in 
      Prostate Cancer Cells by Inhibiting PI3K/Akt Signaling Pathway.
PG  - 305-313
LID - 10.3727/096504016X14666990347437 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha)-induced protein 8-like 2 (TNFAIP8L2, TIPE2) is 
      involved in the invasion and metastasis of human tumors. However, the functional 
      role of TIPE2 in prostate cancer remains unclear. In the present study, we 
      explored the role of TIPE2 in prostate cancer and cancer progression including 
      the molecular mechanism that drives TIPE2-mediated oncogenesis. Our results 
      showed that TIPE2 was lowly expressed in human prostate cancer tissues and cell 
      lines. In addition, restored TIPE2 obviously inhibits proliferation in prostate 
      cancer cells. TIPE2 overexpression also suppresses the epithelial-mesenchymal 
      transition (EMT) process and migration/invasion in prostate cancer cells. 
      Mechanistically, TIPE2 overexpression obviously inhibits the phosphorylation 
      levels of phosphatidylinositol 3-kinase (PI3K) and Akt in prostate cancer cells. 
      In conclusion, for the first time we demonstrated that TIPE2 overexpression may 
      suppress proliferation, migration, and invasion in prostate cancer cells by 
      inhibiting the PI3K/Akt signaling pathway. Therefore, TIPE2 might serve as a 
      potential therapeutic target for human prostate cancer.
FAU - Lu, Qiang
AU  - Lu Q
AD  - Department of Urology, Hunan Provincial People's Hospital, Changsha, Hunan, 
      China.
FAU - Liu, Zhe
AU  - Liu Z
FAU - Li, Zhuo
AU  - Li Z
FAU - Chen, Jia
AU  - Chen J
FAU - Liao, Zhi
AU  - Liao Z
FAU - Wu, Wan-Rui
AU  - Wu WR
FAU - Li, Yuan-Wei
AU  - Li YW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncol Res
JT  - Oncology research
JID - 9208097
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (TNFAIP8L2 protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Movement/physiology
MH  - Cell Proliferation/physiology
MH  - Epithelial-Mesenchymal Transition
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*biosynthesis/genetics/metabolism
MH  - Male
MH  - Neoplasm Invasiveness
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - *Phosphoinositide-3 Kinase Inhibitors
MH  - Prostatic Neoplasms/genetics/*metabolism/*pathology
MH  - Proto-Oncogene Proteins c-akt/*antagonists & inhibitors/metabolism
MH  - Signal Transduction
MH  - Transfection
PMC - PMC7838667
COIS- The authors declare no conflicts of interest.
EDAT- 2016/10/08 06:00
MHDA- 2017/04/06 06:00
PMCR- 2016/09/14
CRDT- 2016/10/08 06:00
PHST- 2016/10/08 06:00 [entrez]
PHST- 2016/10/08 06:00 [pubmed]
PHST- 2017/04/06 06:00 [medline]
PHST- 2016/09/14 00:00 [pmc-release]
AID - OR903 [pii]
AID - 10.3727/096504016X14666990347437 [doi]
PST - ppublish
SO  - Oncol Res. 2016;24(5):305-313. doi: 10.3727/096504016X14666990347437.