PMID- 27715351
OWN - NLM
STAT- MEDLINE
DCOM- 20170405
LR  - 20170405
IS  - 1939-022X (Electronic)
IS  - 1939-0211 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Mar 4
TI  - Yeast beta-Glucan Modulates Inflammation and Waist Circumference in Overweight and 
      Obese Subjects.
PG  - 173-185
AB  - Increased inflammation occurs with excessive adiposity and yeast beta-glucan 
      modulates immune responses. This study investigated the potential effect of yeast 
      beta-glucan on inflammatory cytokines in overweight/obese people. A randomized, 
      double blinded, placebo-controlled, clinical trial design enrolled 44 
      overweight/obese participants with body mass index >/=23 kg/m(2), randomized to two 
      groups receiving beta-glucan 477 mg/capsule (n = 22) or placebo (n = 22) orally for 
      six weeks. At weeks one to two, participants received 1 beta-glucan or placebo 
      capsule/day and at four weeks two tablets/day. Anthropometric changes, lipid 
      profiles, liver and renal functions, and inflammatory cytokines were measured. 
      beta-glucan reduced waist circumference (p = 0.037) and blood pressure (p = 0.006) 
      compared with controls after six weeks of intervention. No statistical 
      significance between groups was observed for triglyceride, cholesterol, lipid 
      profile, liver and renal function, or energy and nutrient intake compared with 
      controls at week six. beta-glucan increased interlukin-10 (IL-10), an 
      anti-inflammatory cytokine, by 23.97% from baseline at week two (p < 0.001) and 
      31.12% at week six (p < 0.001) and was significantly increased compared with 
      controls at week two (p < 0.001) until week six (p < 0.001). beta-glucan reduced 
      pro-inflammatory cytokines IL-6 at week six (p = 0.005) and tumor necrosis 
      factor-alpha at week two (p = 0.037) compared with controls. Supplementation of yeast 
      beta-glucan for six weeks modulated pro-cytokines that accelerate overweight/obese 
      comorbidities and reduced blood pressure as well as waist circumference, the 
      strong risk factors for cardiovascular disease, in overweight/obese subjects. 
      Thus, beta-glucan might have the potential to decrease comorbid conditions 
      associated with overweight/ obesity.
FAU - Mosikanon, Krittiya
AU  - Mosikanon K
AD  - a Institute of Nutrition , Mahidol University , Nakhon Pathom, Thailand.
FAU - Arthan, Dumrongkiet
AU  - Arthan D
AD  - b Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine 
      , Mahidol University , Bangkok , Thailand.
FAU - Kettawan, Aikkarach
AU  - Kettawan A
AD  - a Institute of Nutrition , Mahidol University , Nakhon Pathom, Thailand.
FAU - Tungtrongchitr, Rungsunn
AU  - Tungtrongchitr R
AD  - b Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine 
      , Mahidol University , Bangkok , Thailand.
FAU - Prangthip, Pattaneeya
AU  - Prangthip P
AD  - b Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine 
      , Mahidol University , Bangkok , Thailand.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160811
PL  - England
TA  - J Diet Suppl
JT  - Journal of dietary supplements
JID - 101249830
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta-Glucans)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/drug effects
MH  - Body Mass Index
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*drug therapy/physiopathology
MH  - Overweight/*drug therapy/physiopathology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Waist Circumference/*drug effects
MH  - Yeasts/*chemistry
MH  - Young Adult
MH  - beta-Glucans/*administration & dosage
OTO - NOTNLM
OT  - inflammation
OT  - overweight and obesity
OT  - waist circumference
OT  - yeast beta-glucan
EDAT- 2016/10/08 06:00
MHDA- 2017/04/06 06:00
CRDT- 2016/10/08 06:00
PHST- 2016/10/08 06:00 [pubmed]
PHST- 2017/04/06 06:00 [medline]
PHST- 2016/10/08 06:00 [entrez]
AID - 10.1080/19390211.2016.1207005 [doi]
PST - ppublish
SO  - J Diet Suppl. 2017 Mar 4;14(2):173-185. doi: 10.1080/19390211.2016.1207005. Epub 
      2016 Aug 11.