PMID- 27716276
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20181113
IS  - 1757-7241 (Electronic)
IS  - 1757-7241 (Linking)
VI  - 24
IP  - 1
DP  - 2016 Oct 4
TI  - Elevations in growth hormone and glucagon-like peptide-2 levels on admission are 
      associated with increased mortality in trauma patients.
PG  - 119
LID - 119
AB  - BACKGROUND: Burn and trauma patients present a clinical challenge due to 
      metabolic derangements and hypermetabolism that result in a prolonged catabolic 
      state with impaired healing and secondary complications, including ventilator 
      dependence. Previous work has shown that circulating levels of growth hormone 
      (GH) are predictive of mortality in critically ill adults, but few studies have 
      examined the prognostic potential of GH levels in adult trauma patients. METHODS: 
      To investigate the utility of GH and other endocrine responses in the prediction 
      of outcomes, we conducted a prospective, observational study of adult burn and 
      trauma patients. We evaluated the serum concentration of GH, insulin-like growth 
      factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), and glucagon-like peptide-2 
      (GLP-2) weekly for up to 6 weeks in 36 adult burn and trauma patients admitted 
      between 2010 and 2013. RESULTS: Non-survivors had significantly higher levels of 
      GH and GLP-2 on admission than survivors. DISCUSSION: This study demonstrates 
      that GH has potential as a predictor of mortality in critically ill trauma and 
      burn patients. Future studies will focus on not only the role of GH, but also 
      GLP-2, which was shown to correlate with mortality in this study with a goal of 
      offering early, targeted therapeutic interventions aimed at decreasing mortality 
      in the critically injured. CONCLUSIONS: GH and GLP-2 may have clinical utility 
      for outcome prediction in adult trauma patients.
FAU - Rowan, Matthew P
AU  - Rowan MP
AD  - United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA, Fort 
      Sam Houston, San Antonio, TX, 78234, USA.
FAU - Beckman, Darrick J
AU  - Beckman DJ
AD  - Brooke Army Medical Center, 3855 Roger Brooke Drive, JBSA, Fort Sam Houston, San 
      Antonio, TX, 78234, USA.
FAU - Rizzo, Julie A
AU  - Rizzo JA
AD  - United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA, Fort 
      Sam Houston, San Antonio, TX, 78234, USA. julie.a.rizzo.mil@mail.mil.
AD  - Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd # 
      A3007, Bethesda, MD, 20814, USA. julie.a.rizzo.mil@mail.mil.
FAU - Isbell, Claire L
AU  - Isbell CL
AD  - Baylor Scott and White Memorial Hospital, 2401 S. 31st St, Temple, TX, 76502, 
      USA.
FAU - White, Christopher E
AU  - White CE
AD  - Brooke Army Medical Center, 3855 Roger Brooke Drive, JBSA, Fort Sam Houston, San 
      Antonio, TX, 78234, USA.
FAU - Cohn, Stephen M
AU  - Cohn SM
AD  - Staten Island University Hospital, 475 Seaview Ave, Staten Island, NY, 10305, 
      USA.
FAU - Chung, Kevin K
AU  - Chung KK
AD  - United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA, Fort 
      Sam Houston, San Antonio, TX, 78234, USA.
AD  - Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd # 
      A3007, Bethesda, MD, 20814, USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20161004
PL  - England
TA  - Scand J Trauma Resusc Emerg Med
JT  - Scandinavian journal of trauma, resuscitation and emergency medicine
JID - 101477511
RN  - 0 (Glucagon-Like Peptide 2)
RN  - 0 (IGFBP3 protein, human)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Female
MH  - Glucagon-Like Peptide 2/*blood
MH  - Hospitalization
MH  - Human Growth Hormone/*blood
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Wounds and Injuries/*blood/diagnosis/*mortality
PMC - PMC5050752
OTO - NOTNLM
OT  - Biomarker
OT  - Burn
OT  - Hormone
OT  - Hypermetabolism
OT  - Trauma
EDAT- 2016/10/08 06:00
MHDA- 2017/04/25 06:00
PMCR- 2016/10/04
CRDT- 2016/10/08 06:00
PHST- 2016/05/11 00:00 [received]
PHST- 2016/09/27 00:00 [accepted]
PHST- 2016/10/08 06:00 [entrez]
PHST- 2016/10/08 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2016/10/04 00:00 [pmc-release]
AID - 10.1186/s13049-016-0310-8 [pii]
AID - 310 [pii]
AID - 10.1186/s13049-016-0310-8 [doi]
PST - epublish
SO  - Scand J Trauma Resusc Emerg Med. 2016 Oct 4;24(1):119. doi: 
      10.1186/s13049-016-0310-8.