PMID- 27718161
OWN - NLM
STAT- MEDLINE
DCOM- 20170414
LR  - 20181113
IS  - 1573-0832 (Electronic)
IS  - 0301-486X (Linking)
VI  - 182
IP  - 3-4
DP  - 2017 Apr
TI  - HIV Immune Recovery Inflammatory Syndrome and Central Nervous System 
      Paracoccidioidomycosis.
PG  - 393-396
LID - 10.1007/s11046-016-0076-6 [doi]
AB  - The immune reconstitution inflammatory syndrome (IRIS) is a deregulated 
      inflammatory response to invading microorganisms. It is manifested when there is 
      an abrupt change in host immunity from an anti-inflammatory and immunosuppressive 
      state to a pro-inflammatory state as a result of rapid depletion or removal of 
      factors that promote immune suppression or inhibition of inflammation. The aim of 
      this paper is to discuss and re-interpret the possibility of association of 
      paracoccidioidomycosis (PCM) with IRIS in the central nervous system (CNS) in a 
      case from Brazil published by Silva-Vergara ML. et al. (Mycopathologia 
      177:137-141, 6). An AIDS patient who was not receiving medical care developed 
      pulmonary PCM successfully treated with itraconazole. The patient developed 
      central nervous system PCM (NPCM) after starting the ARV therapy with recovery of 
      immunity and control of HIV viral load, although it was not interpreted as IRIS 
      by the authors, it fulfills the criteria for CNS IRIS. This could be the first 
      case of NPCM associated with IRIS described. Although not frequent, IRIS must be 
      considered in PCM patients and HIV, from endemic areas or patients that traveled 
      to endemic areas, receiving ARV treatment and with worsening symptoms.
FAU - de Almeida, Sergio Monteiro
AU  - de Almeida SM
AD  - Universidade Federal do Parana, Curitiba, Parana, Brazil. sergio.ma@ufpr.br.
AD  - Faculdades Pequeno Principe, Curitiba, Parana, Brazil. sergio.ma@ufpr.br.
AD  - Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Parana, Brazil. 
      sergio.ma@ufpr.br.
AD  - Secao de Virologia, Setor Analises Clinicas, Hospital de Clinicas - UFPR, Rua 
      Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil. sergio.ma@ufpr.br.
FAU - Roza, Thiago Henrique
AU  - Roza TH
AD  - Universidade Federal do Parana, Curitiba, Parana, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161007
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adult
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Brazil
MH  - Central Nervous System Fungal Infections/*diagnosis/pathology
MH  - HIV Infections/*complications/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*etiology/pathology
MH  - Male
MH  - Paracoccidioidomycosis/*diagnosis/*pathology
OTO - NOTNLM
OT  - Central nervous system
OT  - HIV
OT  - IRIS
OT  - Immune recovery inflammatory syndrome
OT  - Neuroparacoccidioidomycosis
OT  - Paracoccidioides brasiliensis
OT  - Paracoccidioidomycosis
EDAT- 2016/10/09 06:00
MHDA- 2017/04/15 06:00
CRDT- 2016/10/09 06:00
PHST- 2016/09/19 00:00 [received]
PHST- 2016/10/02 00:00 [accepted]
PHST- 2016/10/09 06:00 [pubmed]
PHST- 2017/04/15 06:00 [medline]
PHST- 2016/10/09 06:00 [entrez]
AID - 10.1007/s11046-016-0076-6 [pii]
AID - 10.1007/s11046-016-0076-6 [doi]
PST - ppublish
SO  - Mycopathologia. 2017 Apr;182(3-4):393-396. doi: 10.1007/s11046-016-0076-6. Epub 
      2016 Oct 7.