PMID- 27718509
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20181108
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 140
IP  - 1
DP  - 2017 Jan
TI  - Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term 
      cocaine-induced neuroplasticity: a possible novel target for addiction treatment.
PG  - 114-125
LID - 10.1111/jnc.13863 [doi]
AB  - Cocaine addiction is a chronic relapsing disorder characterized by the loss of 
      control over drug-seeking and taking, and continued drug use regardless of 
      adverse consequences. Despite years of research, effective treatments for 
      psycho-stimulant addiction have not been identified. Persistent vulnerability to 
      relapse arises from a number of long-lasting adaptations in the reward circuitry 
      that mediate the enduring response to the drug. Recently, we reported that the 
      activity of the canonical or Wnt/beta-catenin pathway in the prefrontal cortex (PFC) 
      is very important in the early stages of cocaine-induced neuroadaptations. In the 
      present work, our main goal was to elucidate the relevance of this pathway in 
      cocaine-induced long-term neuroadaptations that may underlie relapse. We found 
      that a cocaine challenge, after a period of abstinence, induced an increase in 
      the activity of the pathway which is revealed as an increase in the total and 
      nuclear levels of beta-catenin (final effector of the pathway) in the nucleus 
      accumbens (NAcc), together with a decrease in the activity of glycogen synthase 
      kinase 3beta (GSK3beta). Moreover, we found that the pharmacological modulation of the 
      activity of the pathway has long-term effects on the cocaine-induced 
      neuroplasticity at behavioral and molecular levels. All the results imply that 
      changes in the Wnt/beta-catenin pathway effectors are long-term neuroadaptations 
      necessary for the behavioral response to cocaine. Even though more research is 
      needed, the present results introduce the Wnt canonical pathway as a possible 
      target to manage cocaine long-term neuroadaptations.
CI  - (c) 2016 International Society for Neurochemistry.
FAU - Cuesta, Santiago
AU  - Cuesta S
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rosario, 
      Argentina.
AD  - Area Toxicologia, Departamento de Ciencias de los Alimentos y del Medioambiente, 
      Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
FAU - Batuecas, Jorgelina
AU  - Batuecas J
AD  - Area Toxicologia, Departamento de Ciencias de los Alimentos y del Medioambiente, 
      Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
FAU - Severin, Maria J
AU  - Severin MJ
AD  - Area Toxicologia, Departamento de Ciencias de los Alimentos y del Medioambiente, 
      Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
FAU - Funes, Alejandrina
AU  - Funes A
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rosario, 
      Argentina.
AD  - Area Toxicologia, Departamento de Ciencias de los Alimentos y del Medioambiente, 
      Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
FAU - Rosso, Silvana B
AU  - Rosso SB
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rosario, 
      Argentina.
AD  - Area Toxicologia, Departamento de Ciencias de los Alimentos y del Medioambiente, 
      Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
FAU - Pacchioni, Alejandra M
AU  - Pacchioni AM
AUID- ORCID: 0000-0002-1665-6157
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rosario, 
      Argentina.
AD  - Area Toxicologia, Departamento de Ciencias de los Alimentos y del Medioambiente, 
      Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161207
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (beta Catenin)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Cocaine/*administration & dosage
MH  - Cocaine-Related Disorders/drug therapy/*metabolism
MH  - Drug Delivery Systems
MH  - Male
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Wnt Signaling Pathway/drug effects/*physiology
MH  - beta Catenin/*biosynthesis
OTO - NOTNLM
OT  - Wnt canonical pathway
OT  - cocaine
OT  - lithium chloride
OT  - long-term neuroadaptations
OT  - nucleus accumbens
EDAT- 2016/10/09 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/10/09 06:00
PHST- 2016/07/02 00:00 [received]
PHST- 2016/09/05 00:00 [revised]
PHST- 2016/09/28 00:00 [accepted]
PHST- 2016/10/09 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/10/09 06:00 [entrez]
AID - 10.1111/jnc.13863 [doi]
PST - ppublish
SO  - J Neurochem. 2017 Jan;140(1):114-125. doi: 10.1111/jnc.13863. Epub 2016 Dec 7.