PMID- 27720842
OWN - NLM
STAT- MEDLINE
DCOM- 20171225
LR  - 20191210
IS  - 1873-4596 (Electronic)
IS  - 0891-5849 (Linking)
VI  - 101
DP  - 2016 Dec
TI  - Redox sensitivity of the MyD88 immune signaling adapter.
PG  - 93-101
LID - S0891-5849(16)30446-4 [pii]
LID - 10.1016/j.freeradbiomed.2016.10.004 [doi]
AB  - The transcription factor nuclear factor-kappaB (NF-kappaB) mediates expression of key 
      genes involved in innate immunity and inflammation. NF-kappaB activation has been 
      repeatedly reported to be modulated by hydrogen peroxide (H(2)O(2)). Here, we 
      show that the NF-kappaB-activating signaling adapter myeloid differentiation primary 
      response gene 88 (MyD88) is highly sensitive to oxidation by H(2)O(2) and may be 
      redox-regulated in its function, thus facilitating an influence of H(2)O(2) on 
      the NF-kappaB signaling pathway. Upon oxidation, MyD88 forms distinct 
      disulfide-linked conjugates which are reduced by the MyD88-interacting 
      oxidoreductase nucleoredoxin (Nrx). MyD88 cysteine residues functionally modulate 
      MyD88-dependent NF-kappaB activation, suggesting a link between MyD88 thiol oxidation 
      state and immune signaling.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Stottmeier, Benjamin
AU  - Stottmeier B
AD  - Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center 
      (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
FAU - Dick, Tobias P
AU  - Dick TP
AD  - Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center 
      (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address: 
      t.dick@dkfz.de.
LA  - eng
PT  - Journal Article
DEP - 20161005
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Disulfides)
RN  - 0 (MYD88 protein, human)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Nuclear Proteins)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.- (nucleoredoxin)
RN  - EC 1.13.12.- (Luciferases)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cysteine/chemistry/metabolism
MH  - Disulfides/chemistry/metabolism
MH  - Gene Expression Regulation
MH  - Genes, Reporter
MH  - HEK293 Cells
MH  - Haploidy
MH  - Humans
MH  - Hydrogen Peroxide/*pharmacology
MH  - Immunity, Innate
MH  - Luciferases/genetics/metabolism
MH  - Myeloid Differentiation Factor 88/genetics/*immunology
MH  - NF-kappa B/genetics/*immunology
MH  - Nuclear Proteins/genetics/immunology
MH  - Oxidation-Reduction/drug effects
MH  - Oxidoreductases/genetics/immunology
MH  - *Signal Transduction
OTO - NOTNLM
OT  - Hydrogen peroxide
OT  - MyD88
OT  - NF-kappaB
OT  - Redox signaling
OT  - Thiol oxidation
EDAT- 2016/11/05 06:00
MHDA- 2017/12/26 06:00
CRDT- 2016/11/05 06:00
PHST- 2016/05/24 00:00 [received]
PHST- 2016/09/19 00:00 [revised]
PHST- 2016/10/03 00:00 [accepted]
PHST- 2016/11/05 06:00 [pubmed]
PHST- 2017/12/26 06:00 [medline]
PHST- 2016/11/05 06:00 [entrez]
AID - S0891-5849(16)30446-4 [pii]
AID - 10.1016/j.freeradbiomed.2016.10.004 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2016 Dec;101:93-101. doi: 
      10.1016/j.freeradbiomed.2016.10.004. Epub 2016 Oct 5.