PMID- 27725211
OWN - NLM
STAT- MEDLINE
DCOM- 20171121
LR  - 20180326
IS  - 1556-1380 (Electronic)
IS  - 1556-0864 (Linking)
VI  - 12
IP  - 2
DP  - 2017 Feb
TI  - Prophylactic Cranial Irradiation for Patients with Surgically Resected Small Cell 
      Lung Cancer.
PG  - 347-353
LID - S1556-0864(16)31139-X [pii]
LID - 10.1016/j.jtho.2016.09.133 [doi]
AB  - INTRODUCTION: Data on prophylactic cranial irradiation (PCI) after complete 
      resection of SCLC are limited. The purpose of this study was to investigate the 
      impact of PCI in this population. METHODS: We retrospectively identified 
      completely resected SCLC at the Shanghai Chest Hospital between January 2006 and 
      January 2014. RESULTS: A total of 349 patients (115 patients who received PCI 
      [the PCI-treated cohort] and 234 patients who did not [the non-PCI-treated 
      cohort]) were included in the study. The results demonstrated that the 
      PCI-treated cohort had longer overall survival than the non-PCI-treated cohort 
      among patients with pathologic stage (p-stage) II (hazard ratio [HR] = 0.54, 95% 
      confidence interval [CI]: 0.30-0.99, p = 0.047) and p-stage III (HR = 0.54, 95% 
      CI: 0.34-0.86, p = 0.009) disease. Among patients with p-stage III disease, there 
      was a significantly higher risk for cerebral recurrence from the time of 
      diagnosis in the non-PCI-treated cohort (p = 0.018). With regard to patients with 
      p-stage I disease, neither overall survival benefit (HR = 1.61, 95% CI: 
      0.68-3.83, p = 0.282) nor risk for cerebral recurrence (p = 0.389) was 
      significant between the PCI-treated and non-PCI-treated cohorts. CONCLUSIONS: The 
      data presented in the current study support using PCI in patients with p-stage 
      II/III disease but not in patients with p-stage I disease. A relatively lower 
      risk for brain metastases in p-stage I patients might explain the inferior 
      efficacy of PCI in this population.
CI  - Copyright (c) 2016 International Association for the Study of Lung Cancer. 
      Published by Elsevier Inc. All rights reserved.
FAU - Xu, Jianlin
AU  - Xu J
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Yang, Haitang
AU  - Yang H
AD  - Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong 
      University, Shanghai, People's Republic of China.
FAU - Fu, Xiaolong
AU  - Fu X
AD  - Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiaotong 
      University, Shanghai, People's Republic of China.
FAU - Jin, Bo
AU  - Jin B
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Lou, Yuqing
AU  - Lou Y
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Zhang, Yanwei
AU  - Zhang Y
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Zhang, Xueyan
AU  - Zhang X
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Zhong, Hua
AU  - Zhong H
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Wang, Huimin
AU  - Wang H
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Wu, Dan
AU  - Wu D
AD  - Central Laboratory, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China.
FAU - Han, Baohui
AU  - Han B
AD  - Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai, People's Republic of China. Electronic address: xkyyhan@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161007
PL  - United States
TA  - J Thorac Oncol
JT  - Journal of thoracic oncology : official publication of the International 
      Association for the Study of Lung Cancer
JID - 101274235
SB  - IM
CIN - J Thorac Oncol. 2017 Feb;12 (2):173-175. PMID: 28115108
CIN - Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):3-5. PMID: 28816157
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*epidemiology/etiology/secondary
MH  - China
MH  - Cranial Irradiation/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Lung Neoplasms/pathology/*radiotherapy/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Small Cell Lung Carcinoma/pathology/*radiotherapy/surgery
MH  - Survival Rate
OTO - NOTNLM
OT  - Lung cancer
OT  - Prophylactic cranial irradiation
OT  - Resected
OT  - Small cell
EDAT- 2016/10/12 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/10/12 06:00
PHST- 2016/04/18 00:00 [received]
PHST- 2016/08/06 00:00 [revised]
PHST- 2016/09/25 00:00 [accepted]
PHST- 2016/10/12 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/10/12 06:00 [entrez]
AID - S1556-0864(16)31139-X [pii]
AID - 10.1016/j.jtho.2016.09.133 [doi]
PST - ppublish
SO  - J Thorac Oncol. 2017 Feb;12(2):347-353. doi: 10.1016/j.jtho.2016.09.133. Epub 
      2016 Oct 7.