PMID- 27725273
OWN - NLM
STAT- MEDLINE
DCOM- 20170831
LR  - 20180409
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 150-151
DP  - 2016 Nov-Dec
TI  - MDMA ('Ecstasy'), oxytocin and vasopressin modulate social preference in rats: A 
      role for handling and oxytocin receptors.
PG  - 115-123
LID - S0091-3057(16)30167-8 [pii]
LID - 10.1016/j.pbb.2016.10.002 [doi]
AB  - In laboratory rats, peripheral administration of the neuropeptides oxytocin (OT) 
      and vasopressin (AVP) induces similar prosocial effects (i.e. increased adjacent 
      lying) to the party drug 3,4-methylenedioxymethamphetamine (MDMA), which are 
      sensitive to vasopressin V(1A) receptor (V(1A)R) antagonism. Here, we employed a 
      social preference paradigm to further compare the prosocial effects of OT, AVP 
      and MDMA. We also investigated the possible involvement of the V(1A)R and 
      oxytocin receptor (OTR) in rodent social preference. The social preference 
      paradigm measures investigation times towards an empty wire cage (presented for 
      4min) followed by an identical cage containing a novel rat (also presented for 
      4min). Social preference is defined as greater investigation time towards the 
      inhabited cage than the empty cage. Results indicated that well-handled rats 
      exhibited no social preference at baseline, while intraperitoneally injected MDMA 
      (5mg/kg), OT (0.5mg/kg) and AVP (0.005mg/kg) increased social preference. 
      However, this effect was primarily due to reduced investigation of the empty 
      cage. In contrast, rats that received minimal prior handling displayed a social 
      preference at baseline, while MDMA (5mg/kg), OT (0.5mg/kg) and AVP (0.005mg/kg) 
      reduced investigation times towards both the empty and inhabited cages. Lower 
      doses of MDMA, OT and AVP were ineffective. The OTR antagonist Compound 25 (C25, 
      5mg/kg), but not the V(1A)R antagonist SR49059 (1mg/kg), reduced the baseline 
      social preference seen in minimally-handled rats and prevented the social 
      preference induced by OT and AVP (but not MDMA) in well-handled rats. Overall, 
      these results further confirm prosocial actions of MDMA, OT and AVP, which are 
      dependent on handling history. These findings also indicate that social 
      preference is sensitive to OTR rather than V(1A)R modulation.
CI  - Copyright A(c) 2016 Elsevier Inc. All rights reserved.
FAU - Ramos, Linnet
AU  - Ramos L
AD  - School of Psychology, Brennan MacCallum Building, University of Sydney, NSW 2006, 
      Australia.
FAU - Hicks, Callum
AU  - Hicks C
AD  - School of Psychology, Brennan MacCallum Building, University of Sydney, NSW 2006, 
      Australia.
FAU - Caminer, Alex
AU  - Caminer A
AD  - School of Psychology, Brennan MacCallum Building, University of Sydney, NSW 2006, 
      Australia.
FAU - Couto, Kalliu
AU  - Couto K
AD  - School of Psychology, Brennan MacCallum Building, University of Sydney, NSW 2006, 
      Australia.
FAU - Narlawar, Rajeshwar
AU  - Narlawar R
AD  - School of Chemistry, University of Sydney, NSW 2006, Australia.
FAU - Kassiou, Michael
AU  - Kassiou M
AD  - School of Chemistry, University of Sydney, NSW 2006, Australia.
FAU - McGregor, Iain S
AU  - McGregor IS
AD  - School of Psychology, Brennan MacCallum Building, University of Sydney, NSW 2006, 
      Australia. Electronic address: iain.mcgregor@sydney.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20161007
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Indoles)
RN  - 0 (Pyrrolidines)
RN  - 0 (Receptors, Oxytocin)
RN  - 0 (Receptors, Vasopressin)
RN  - 11000-17-2 (Vasopressins)
RN  - 50-56-6 (Oxytocin)
RN  - C1GL8G6G0O (relcovaptan)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animal Husbandry
MH  - Animals
MH  - Indoles/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Oxytocin/*pharmacology
MH  - Pyrrolidines/pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Oxytocin/*physiology
MH  - Receptors, Vasopressin/physiology
MH  - *Social Behavior
MH  - Vasopressins/*pharmacology
OTO - NOTNLM
OT  - Compound 25
OT  - Handling
OT  - MDMA
OT  - Oxytocin
OT  - SR49059
OT  - Social preference
OT  - Vasopressin
EDAT- 2016/10/26 06:00
MHDA- 2017/09/01 06:00
CRDT- 2016/11/06 06:00
PHST- 2013/09/06 00:00 [received]
PHST- 2016/09/15 00:00 [revised]
PHST- 2016/10/05 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2017/09/01 06:00 [medline]
PHST- 2016/11/06 06:00 [entrez]
AID - S0091-3057(16)30167-8 [pii]
AID - 10.1016/j.pbb.2016.10.002 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2016 Nov-Dec;150-151:115-123. doi: 
      10.1016/j.pbb.2016.10.002. Epub 2016 Oct 7.