PMID- 27725405
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20221207
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 62
IP  - 4
DP  - 2016
TI  - Vitamin D Deficiency in Relation to the Risk of Metabolic Syndrome in Middle-Aged 
      and Elderly Patients with Type 2 Diabetes Mellitus.
PG  - 213-219
AB  - Vitamin D deficiency is highly prevalent all over the world and dietary intakes 
      of vitamin D are very low in China. In this study we aimed to determine whether 
      vitamin D deficiency is associated with increased risk of metabolic syndrome 
      (MetS) among Chinese type 2 diabetes mellitus (T2DM) patients aged over 50 y. 
      Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured in a 
      cross-sectional sample of 270 T2DM patients aged over 50 y from Zhejiang. Data on 
      demographic characteristics, anthropometry and other variables were collected. 
      The mean of serum 25(OH)D was 22.93 ng/mL, and percentages of vitamin D 
      deficiency and insufficiency were 43.71% and 39.63%, respectively. Serum 25(OH)D 
      concentrations were significantly lower in subjects with MetS than in those 
      without MetS (21.74 vs 24.96 ng/mL, p=0.001), and the prevalence of MetS 
      significantly increased according to tertiles of serum 25(OH)D concentrations. 
      After adjusting for multivariate factors, the adverse effect of lower serum 
      25(OH)D concentrations was significant (OR: 3.26, 95% CI: 1.03-7.34; p=0.044) in 
      the group with BMI>/=24 kg/m(2) while the change in OR of MetS for each 10 ng/mL 
      decrease in the serum 25(OH)D concentrations was 2.03 (95% CI: 1.10-3.79). These 
      results suggest that serum 25(OH)D deficiency may be a risk factor of MetS among 
      Chinese type 2 diabetic patients, especially in the T2DM with BMI>/=24 kg/m(2). The 
      challenge is determining the mechanisms of vitamin D action for recommendation of 
      vitamin D supplementation that reduces the risks of MetS and progression to T2DM.
FAU - Pan, Guo-Tao
AU  - Pan GT
AD  - School of Public Health, Soochow University.
FAU - Guo, Jian-Feng
AU  - Guo JF
FAU - Mei, Shao-Lin
AU  - Mei SL
FAU - Zhang, Meng-Xi
AU  - Zhang MX
FAU - Hu, Zhi-Yong
AU  - Hu ZY
FAU - Zhong, Chong-Ke
AU  - Zhong CK
FAU - Zeng, Chang-You
AU  - Zeng CY
FAU - Liu, Xiao-Hong
AU  - Liu XH
FAU - Ma, Qing-Hua
AU  - Ma QH
FAU - Li, Bing-Yan
AU  - Li BY
FAU - Qin, Li-Qiang
AU  - Qin LQ
FAU - Zhang, Zeng-Li
AU  - Zhang ZL
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 1406-16-2 (Vitamin D)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/drug effects
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - China/epidemiology
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Metabolic Syndrome/blood/*epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/*blood/complications
MH  - Waist Circumference
EDAT- 2016/10/12 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/10/12 06:00
PHST- 2016/10/12 06:00 [entrez]
PHST- 2016/10/12 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
AID - 10.3177/jnsv.62.213 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2016;62(4):213-219. doi: 10.3177/jnsv.62.213.