PMID- 27725451
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20170127
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 39
IP  - 10
DP  - 2016
TI  - Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in 
      Hairless Mouse Model of Atopic Dermatitis.
PG  - 1718-1722
AB  - When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a 
      petroleum-containing alkaline salt spring water rich in metaboric acid and sodium 
      bicarbonate, AD symptoms diminished. Reversed-phase HPLC with fluorescence 
      detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of 
      the skin surface lipids was similar to that in non-AD mice compared with that in 
      AD mice. Strong negative correlations were noted between the levels of total 
      serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total 
      serum IgE and branched-hexadecanoic acid. Conversely, a strong positive 
      correlation was noted between the levels of total serum IgE and linoleic acid. 
      The present study demonstrates that the petroleum-containing spring water alters 
      the FA composition of skin surface lipids in AD mice, which can be used as an 
      index to evaluate inflammation.
FAU - Nishimura, Kazuhiko
AU  - Nishimura K
AD  - Hokkaido Institute of Public Health.
FAU - Aoyanagi, Naoki
AU  - Aoyanagi N
FAU - Uchino, Eiji
AU  - Uchino E
FAU - Itabashi, Yutaka
AU  - Itabashi Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Fatty Acids)
RN  - 0 (Petroleum)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - D241E059U6 (Dinitrofluorobenzene)
SB  - IM
MH  - Animals
MH  - Dermatitis, Atopic/blood/chemically induced/*metabolism
MH  - Dinitrofluorobenzene
MH  - Disease Models, Animal
MH  - Fatty Acids/*metabolism
MH  - *Hot Springs
MH  - Immunoglobulin E/blood
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Mice, Hairless
MH  - *Petroleum
MH  - Skin/*metabolism
EDAT- 2016/10/12 06:00
MHDA- 2017/01/28 06:00
CRDT- 2016/10/12 06:00
PHST- 2016/10/12 06:00 [entrez]
PHST- 2016/10/12 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 10.1248/bpb.b16-00275 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2016;39(10):1718-1722. doi: 10.1248/bpb.b16-00275.