PMID- 27726307
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20171128
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 33
IP  - 3
DP  - 2017 Mar
TI  - High prevalence of diabetes-specific autoimmunity in first-degree relatives of 
      Sardinian patients with type 1 diabetes.
LID - 10.1002/dmrr.2864 [doi]
AB  - BACKGROUND: The incidence of type 1 diabetes mellitus (T1DM) in Sardinia is among 
      the highest in the world (44.8 cases/100,000 person-years). Recommendations of 
      the Immunology of Diabetes Society advise evaluating autoantibody positivity in 
      first-degree relatives (FDRs) of patients with T1DM, for their higher risk to 
      develop the disease. The aim of this study was to determine the prevalence of 
      beta-cell autoimmunity in FDRs of T1DM patients in Sardinia. METHODS: A total of 
      188 Sardinian families were recruited in collaboration between diabetes and 
      pediatric units of university and district hospitals in Sardinia. The recruitment 
      involved 188 patients with diagnosed T1DM and all their available FDRs (n = 447). 
      Autoantibodies (Aabs) against GAD, IA2, insulin, and ZnT8 were measured in all 
      subjects. Human leukocyte antigen (HLA) risk genotypes (HLA-DR and DQ loci) were 
      analyzed in 43 Aabs-positive FDR. RESULTS: The prevalence of Aabs (any type of 
      autoantibody, single or multiple) in FDR was 11.9% (53/447). Of those with 
      autoantibodies, 62.3% (33/53) were positive to only 1 autoantibody, 22.6% (12/53) 
      had 2 autoantibodies, 7.55% (4/53) had 3 autoantibodies, and 7.55% (4/53) had all 
      4 autoantibodies. Typing of HLA-DR and DQ loci showed that 89% of FDR carried 
      moderate- to high-risk genotypes, with only 5 FDR with low-risk genotypes. 
      CONCLUSIONS: The prevalence of T1DM autoantibodies in FDRs of T1DM patients was 
      very high (11.9%) in the Sardinian population, higher than in other populations 
      from the United States and Europe, and similar to that observed in Finland. 
      Autoantibody positivity strongly associated with HLA risk. This study provides 
      evidence of the high risk of T1DM in FDR of T1DM patients in Sardinia and 
      warrants longitudinal follow-up to estimate the risk of progression to T1DM in 
      high-risk populations.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Incani, M
AU  - Incani M
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Serafini, C
AU  - Serafini C
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Satta, C
AU  - Satta C
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Perra, L
AU  - Perra L
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Scano, F
AU  - Scano F
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Frongia, P
AU  - Frongia P
AD  - Paediatric Unit, San Michele Hospital, Cagliari, Italy.
FAU - Ricciardi, R
AU  - Ricciardi R
AD  - Paediatric Unit, San Michele Hospital, Cagliari, Italy.
FAU - Ripoli, C
AU  - Ripoli C
AD  - Diabetes Paediatric Unit, San Michele Hospital, Cagliari, Italy.
FAU - Soro, M
AU  - Soro M
AD  - Paediatric Unit, San Martino Hospital, Oristano, Italy.
FAU - Strazzera, A
AU  - Strazzera A
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Zampetti, S
AU  - Zampetti S
AD  - Endocrinology, Department Experimental Medicine, Sapienza University of Rome, 
      Italy.
FAU - Buzzetti, R
AU  - Buzzetti R
AD  - Endocrinology, Department Experimental Medicine, Sapienza University of Rome, 
      Italy.
FAU - Cavallo, M G
AU  - Cavallo MG
AD  - Internal Medicine Unit, Department of Internal Medicine and Medical Specialties, 
      Sapienza University of Rome, Italy.
FAU - Cossu, E
AU  - Cossu E
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
FAU - Baroni, M G
AU  - Baroni MG
AUID- ORCID: 0000-0002-3224-6078
AD  - Endocrinology and Diabetes, Department of Medical Sciences, University of 
      Cagliari, Italy.
AD  - Endocrinology, Department Experimental Medicine, Sapienza University of Rome, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161130
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/*immunology
MH  - Autoimmune Diseases/*epidemiology/genetics/immunology
MH  - Autoimmunity/*immunology
MH  - Biomarkers/analysis
MH  - Child
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Family
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*immunology
MH  - HLA-DR Antigens/*immunology
MH  - Humans
MH  - Islets of Langerhans/*immunology
MH  - Italy/epidemiology
MH  - Male
MH  - Prevalence
MH  - Prognosis
MH  - Young Adult
OTO - NOTNLM
OT  - HLA risk
OT  - Sardinia
OT  - Type 1 diabetes mellitus
OT  - autoantibodies
OT  - first-degree relatives
EDAT- 2016/10/12 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/10/12 06:00
PHST- 2016/04/11 00:00 [received]
PHST- 2016/09/16 00:00 [revised]
PHST- 2016/10/07 00:00 [accepted]
PHST- 2016/10/12 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/10/12 06:00 [entrez]
AID - 10.1002/dmrr.2864 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2017 Mar;33(3). doi: 10.1002/dmrr.2864. Epub 2016 Nov 30.