PMID- 27727242
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20220317
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 6
IP  - 10
DP  - 2016 Oct 11
TI  - Data-driven classification of bipolar I disorder from longitudinal course of 
      mood.
PG  - e912
LID - 10.1038/tp.2016.166 [doi]
AB  - The Diagnostic and Statistical Manual of Mental Disorder (DSM) classification of 
      bipolar disorder defines categories to reflect common understanding of mood 
      symptoms rather than scientific evidence. This work aimed to determine whether 
      bipolar I can be objectively classified from longitudinal mood data and whether 
      resulting classes have clinical associations. Bayesian nonparametric hierarchical 
      models with latent classes and patient-specific models of mood are fit to data 
      from Longitudinal Interval Follow-up Evaluations (LIFE) of bipolar I patients 
      (N=209). Classes are tested for clinical associations. No classes are justified 
      using the time course of DSM-IV mood states. Three classes are justified using 
      the course of subsyndromal mood symptoms. Classes differed in attempted suicides 
      (P=0.017), disability status (P=0.012) and chronicity of affective symptoms 
      (P=0.009). Thus, bipolar I disorder can be objectively classified from mood 
      course, and individuals in the resulting classes share clinical features. 
      Data-driven classification from mood course could be used to enrich sample 
      populations for pharmacological and etiological studies.
FAU - Cochran, A L
AU  - Cochran AL
AD  - Department of Mathematics, University of Michigan, Ann Arbor, MI, USA.
FAU - McInnis, M G
AU  - McInnis MG
AD  - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
FAU - Forger, D B
AU  - Forger DB
AD  - Department of Mathematics, University of Michigan, Ann Arbor, MI, USA.
AD  - Department of Computational Medicine and Bioinformatics, University of Michigan, 
      Ann Arbor, MI, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161011
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
MH  - Adult
MH  - *Affect
MH  - Bipolar Disorder/*classification/diagnosis/*psychology
MH  - Chronic Disease
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Suicide, Attempted/psychology
PMC - PMC5315544
COIS- The authors declare no conflict of interest.
EDAT- 2016/10/12 06:00
MHDA- 2017/12/05 06:00
PMCR- 2016/10/01
CRDT- 2016/10/12 06:00
PHST- 2016/05/19 00:00 [received]
PHST- 2016/06/01 00:00 [accepted]
PHST- 2016/10/12 06:00 [entrez]
PHST- 2016/10/12 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - tp2016166 [pii]
AID - 10.1038/tp.2016.166 [doi]
PST - epublish
SO  - Transl Psychiatry. 2016 Oct 11;6(10):e912. doi: 10.1038/tp.2016.166.