PMID- 27728803
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20220129
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 30
IP  - 4
DP  - 2016 Oct 10
TI  - SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell 
      Carcinoma from Different Cells of Origin.
PG  - 519-532
LID - S1535-6108(16)30436-6 [pii]
LID - 10.1016/j.ccell.2016.09.001 [doi]
AB  - Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective 
      treatments, due to its complex genomic profile. Therefore, preclinical models 
      mimicking its salient features are urgently needed. Here we describe mouse models 
      bearing various combinations of genetic lesions predominantly found in human 
      LSCC. We show that SOX2 but not FGFR1 overexpression in tracheobronchial basal 
      cells combined with Cdkn2ab and Pten loss results in LSCC closely resembling the 
      human counterpart. Interestingly, Sox2;Pten;Cdkn2ab mice develop LSCC with a more 
      peripheral location when Club or Alveolar type 2 (AT2) cells are targeted. Our 
      model highlights the essential role of SOX2 in commanding the squamous cell fate 
      from different cells of origin and represents an invaluable tool for developing 
      better intervention strategies.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Ferone, Giustina
AU  - Ferone G
AD  - Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 
      121, 1066 CX Amsterdam, the Netherlands.
FAU - Song, Ji-Ying
AU  - Song JY
AD  - Division of Experimental Animal Pathology, The Netherlands Cancer Institute, 
      Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
FAU - Sutherland, Kate D
AU  - Sutherland KD
AD  - ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of 
      Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, 
      The University of Melbourne, Parkville, VIC 3010, Australia.
FAU - Bhaskaran, Rajith
AU  - Bhaskaran R
AD  - Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 
      121, 1066 CX Amsterdam, the Netherlands; Skolkovo Institute of Science and 
      Technology, Skolkovo Innovation Center, Building 5, Moscow 143026, Russia.
FAU - Monkhorst, Kim
AU  - Monkhorst K
AD  - Division of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX 
      Amsterdam, the Netherlands.
FAU - Lambooij, Jan-Paul
AU  - Lambooij JP
AD  - Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 
      121, 1066 CX Amsterdam, the Netherlands.
FAU - Proost, Natalie
AU  - Proost N
AD  - Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 
      121, 1066 CX Amsterdam, the Netherlands.
FAU - Gargiulo, Gaetano
AU  - Gargiulo G
AD  - Department of Molecular Oncology, Max-Delbruck-Center for Molecular Medicine, 
      Robert-Rossle-Strasse 10, 13092 Berlin, Germany.
FAU - Berns, Anton
AU  - Berns A
AD  - Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 
      121, 1066 CX Amsterdam, the Netherlands; Skolkovo Institute of Science and 
      Technology, Skolkovo Innovation Center, Building 5, Moscow 143026, Russia. 
      Electronic address: a.berns@nki.nl.
LA  - eng
GR  - 14-0433/AICR_/Worldwide Cancer Research/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Sox2 protein, mouse)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
SB  - IM
CIN - Cancer Cell. 2016 Oct 10;30(4):505-507. PMID: 27728797
CIN - J Thorac Dis. 2017 Jan;9(1):E85-E86. PMID: 28203443
MH  - Animals
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/*pathology
MH  - Cell Proliferation/genetics
MH  - Disease Models, Animal
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/*genetics/metabolism/*pathology
MH  - Mice
MH  - Receptor, Fibroblast Growth Factor, Type 1/biosynthesis/genetics
MH  - SOXB1 Transcription Factors/*genetics
MH  - Transcription, Genetic
MH  - Tumor Microenvironment
PMC - PMC5065004
EDAT- 2016/10/12 06:00
MHDA- 2017/08/22 06:00
PMCR- 2016/10/10
CRDT- 2016/10/12 06:00
PHST- 2016/03/03 00:00 [received]
PHST- 2016/07/05 00:00 [revised]
PHST- 2016/09/07 00:00 [accepted]
PHST- 2016/10/12 06:00 [entrez]
PHST- 2016/10/12 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
PHST- 2016/10/10 00:00 [pmc-release]
AID - S1535-6108(16)30436-6 [pii]
AID - 10.1016/j.ccell.2016.09.001 [doi]
PST - ppublish
SO  - Cancer Cell. 2016 Oct 10;30(4):519-532. doi: 10.1016/j.ccell.2016.09.001.