PMID- 27729056
OWN - NLM
STAT- MEDLINE
DCOM- 20171108
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 18
IP  - 1
DP  - 2016 Oct 12
TI  - Inflammatory cell infiltrates in the heart of patients with coronary artery 
      disease with and without inflammatory rheumatic disease: a biopsy study.
PG  - 232
LID - 232
AB  - BACKGROUND: The cause of premature cardiovascular disease (CVD) in inflammatory 
      rheumatic diseases (IRDs) has not been fully elucidated. As inflammation may play 
      a role, we wanted to compare the occurrence and extent of inflammatory cell 
      infiltrates (ICIs), small vessel vasculitis, and the amount of adipose tissue and 
      collagen in cardiac biopsies taken from patients with coronary artery disease 
      with and without IRDs. METHODS: From among the Feiring Heart Biopsy Study 
      subjects, we selected patients undergoing coronary artery bypass grafting from 
      whom paraffin-embedded, formalin-fixed specimens from the right atrium were 
      available. The sample comprised 48 patients with IRD and 40 non-IRD patients. 
      Hematoxylin and eosin staining was used to examine the presence and location of 
      ICIs and vasculitis, and Lendrum (Martius yellow, scarlet, and blue) staining was 
      carried out for collagen and adipose tissue. RESULTS: Epicardial ICIs were found 
      in 27 (56 %) patients with IRD and 24 (60 %) non-IRD patients. There were no 
      significant differences between patients with IRD and non-IRD patients in the 
      amount of cardiac ICIs and adipose tissue, but patients with IRD had more 
      collagen in the myocardium than non-IRD patients. Small vessel vasculitis was not 
      observed in any cardiac specimen. Patients with epicardial ICIs were, on average, 
      7 years younger than those without. CONCLUSIONS: Our results do not support the 
      notion that inflammation in cardiac peri-, epi-, and myocardium plays a more 
      important role in CVD of patients with IRD than non-IRD patients. The increased 
      amount of collagen in the myocardium of patients with IRD suggests differences in 
      extracellular matrix composition and/or mass, which might play a role in cardiac 
      remodeling, and represent targets for novel therapies against heart failure.
FAU - Andersen, Jacqueline K
AU  - Andersen JK
AD  - Department of Health, Technology and Society, Norwegian University of Science and 
      Technology (NTNU), Teknologiveien 22, 2815, Gjovik, Norway. 
      jacqueline.andersen@ntnu.no.
FAU - Oma, Ingvild
AU  - Oma I
AD  - Department of Pathology, Innlandet Hospital Trust, Lillehammer, Norway.
AD  - Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
FAU - Prayson, Richard A
AU  - Prayson RA
AD  - Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
FAU - Kvelstad, Ingjerd Lien
AU  - Kvelstad IL
AD  - Department of Pathology, Innlandet Hospital Trust, Lillehammer, Norway.
FAU - Almdahl, Sven Martin
AU  - Almdahl SM
AD  - Department of Cardiothoracic and Vascular Surgery, University Hospital of North 
      Norway, Tromso, Norway.
FAU - Fagerland, Morten Wang
AU  - Fagerland MW
AD  - Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo 
      University Hospital, Oslo, Norway.
FAU - Hollan, Ivana
AU  - Hollan I
AD  - Hospital for Rheumatic Diseases, Lillehammer, Norway.
AD  - Department of Research, Innlandet Hospital Trust, Brumunddal, Norway.
AD  - Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
CN  - Feiring Heart Biopsy Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161012
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Coronary Artery Disease/*complications
MH  - Female
MH  - Humans
MH  - Inflammation/pathology
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Pericardium/*pathology
MH  - Rheumatic Diseases/*complications
PMC - PMC5059899
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Collagen
OT  - Endocardium
OT  - Epicardial adipose tissue
OT  - Epicardium
OT  - Extracellular matrix
OT  - Inflammation
OT  - Inflammatory rheumatic diseases
OT  - Myocardium
OT  - Right atrium
EDAT- 2016/10/13 06:00
MHDA- 2017/11/09 06:00
PMCR- 2016/10/12
CRDT- 2016/10/13 06:00
PHST- 2016/07/04 00:00 [received]
PHST- 2016/09/20 00:00 [accepted]
PHST- 2016/10/13 06:00 [entrez]
PHST- 2016/10/13 06:00 [pubmed]
PHST- 2017/11/09 06:00 [medline]
PHST- 2016/10/12 00:00 [pmc-release]
AID - 10.1186/s13075-016-1136-5 [pii]
AID - 1136 [pii]
AID - 10.1186/s13075-016-1136-5 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2016 Oct 12;18(1):232. doi: 10.1186/s13075-016-1136-5.