PMID- 27729261
OWN - NLM
STAT- MEDLINE
DCOM- 20170529
LR  - 20180304
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 151
IP  - 3
DP  - 2017 Mar
TI  - Dendritic Cells in Human Lung Disease: Recent Advances.
PG  - 668-673
LID - S0012-3692(16)59355-6 [pii]
LID - 10.1016/j.chest.2016.09.030 [doi]
AB  - Dendritic cells (DCs) are potent antigen-presenting cells. Because of their 
      particular ability to initiate and regulate cell mediated and humoral immune 
      responses, there is considerable interest in the role that DCs play in the 
      pathogenesis of various lung diseases, especially those in which there is an 
      excessive immune response to specific antigens (as in asthma) or a deficient 
      immune response (as in lung cancer). A number of DC subpopulations have been 
      defined in the lungs, including myeloid or conventional DCs that initiate T-cell 
      immunity and antibody production and plasmacytoid DCs that have an important role 
      in antiviral immunity and immune tolerance. Although an extensive body of 
      literature has documented the role that DCs play in experimental models of lung 
      disease, this review will highlight recent advances in our understanding of DC 
      function in human disease, including asthma, COPD, antimicrobial immunity, and 
      lung cancer. The future is likely to see new approaches whereby antigens and 
      small molecules are targeted to receptors on particular DC subpopulations in 
      order to modify pulmonary immune responses.
CI  - Copyright (c) 2016 American College of Chest Physicians. Published by Elsevier Inc. 
      All rights reserved.
FAU - Upham, John W
AU  - Upham JW
AD  - School of Medicine, The University of Queensland, Translational Research 
      Institute, Woolloongabba, Brisbane, Australia; Department of Respiratory 
      Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia. Electronic 
      address: j.upham@uq.edu.au.
FAU - Xi, Yang
AU  - Xi Y
AD  - School of Medicine, The University of Queensland, Translational Research 
      Institute, Woolloongabba, Brisbane, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161008
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Asthma/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lung/immunology/microbiology
MH  - Lung Diseases/immunology
MH  - Lung Neoplasms/*immunology
MH  - Mesothelioma/*immunology
MH  - Microbiota/immunology
MH  - Pneumonia/*immunology
MH  - Pulmonary Disease, Chronic Obstructive/*immunology
MH  - T-Lymphocytes/immunology
OTO - NOTNLM
OT  - dendritic cells
OT  - immune regulation
EDAT- 2016/10/13 06:00
MHDA- 2017/05/30 06:00
CRDT- 2016/10/13 06:00
PHST- 2016/03/22 00:00 [received]
PHST- 2016/08/18 00:00 [revised]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2016/10/13 06:00 [pubmed]
PHST- 2017/05/30 06:00 [medline]
PHST- 2016/10/13 06:00 [entrez]
AID - S0012-3692(16)59355-6 [pii]
AID - 10.1016/j.chest.2016.09.030 [doi]
PST - ppublish
SO  - Chest. 2017 Mar;151(3):668-673. doi: 10.1016/j.chest.2016.09.030. Epub 2016 Oct 
      8.