PMID- 27729362
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20221207
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Print)
IS  - 1941-9651 (Linking)
VI  - 9
IP  - 10
DP  - 2016 Oct
TI  - Association of Impaired Glucose Regulation and Insulin Resistance With Cardiac 
      Structure and Function: Results From ECHO-SOL (Echocardiographic Study of 
      Latinos).
LID - e005032
AB  - BACKGROUND: We examined the relationship between glucose homeostasis and 
      comprehensive measures of cardiac structure and function among a representative 
      sample of US Hispanics. METHODS AND RESULTS: ECHO-SOL (Echocardiographic Study of 
      Latinos), an echocardiographic ancillary study of the HCHS/SOL (Hispanic 
      Community Health Study/Study of Latinos), enrolled 1818 Hispanic/Latino men (43%) 
      and women (57%) aged >/=45 years (mean=56). Glucose intolerance was defined as 
      follows: (1) prediabetes: hemoglobin (HbA1c) >/=5.7 and <6.5% and (2) diabetes 
      mellitus: fasting plasma glucose >/=126 mg/dL, 2-hour postload glucose >/=200 mg/dL, 
      HbA1c >/=6.5%, or hypoglycemic agent use. Uncontrolled diabetes mellitus was 
      defined as HbA1c >/=7.0%. Insulin resistance was defined using the homeostatic 
      model assessment for insulin resistance. Echocardiography examinations assessed 
      left ventricular structure and systolic/diastolic function. Multivariable linear 
      and logistic regression models were used. Prediabetes prevalence was 42%, and 
      diabetes mellitus prevalence was 28% (47% uncontrolled). Glucose intolerance was 
      associated with increased left ventricular posterior wall and interventricular 
      septal and relative wall thicknesses (all P<0.05), reduced ejection fraction 
      (P<0.01), reduced stroke and end-diastolic volumes (both P<0.001), decreased peak 
      E' velocity (lateral and septal P<0.001), and increased E/E' ratio (lateral and 
      septal P<0.01). The odds ratios (95% confidence intervals) for diastolic 
      dysfunction among individuals with prediabetes and diabetes mellitus (versus 
      diabetes mellitus free) were 1.36 (0.96-1.9) and 1.90 (1.3-2.8), 
      respectively(P=0.006). Results were consistent for uncontrolled diabetes mellitus 
      versus diabetes mellitus. Homeostatic model assessment for insulin resistance was 
      associated with increased E/E' (P<0.001), and greater relative wall thickness and 
      septal thickness (both P<0.05); lower stroke volume (P<0.0001); and lower peak 
      lateral and septal E' velocities (both P<0.01). CONCLUSIONS: Glucose intolerance 
      and insulin resistance are associated with unfavorable cardiac structure and 
      function, particularly worsened measures of diastolic function, even before the 
      development of diabetes mellitus.
CI  - (c) 2016 American Heart Association, Inc.
FAU - Demmer, Ryan T
AU  - Demmer RT
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.). 
      rtd2106@cumc.columbia.edu.
FAU - Allison, Matthew A
AU  - Allison MA
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Cai, Jianwen
AU  - Cai J
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Kaplan, Robert C
AU  - Kaplan RC
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Desai, Ankit A
AU  - Desai AA
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Hurwitz, Barry E
AU  - Hurwitz BE
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Newman, Jill C
AU  - Newman JC
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Shah, Sanjiv J
AU  - Shah SJ
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Swett, Katrina
AU  - Swett K
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Talavera, Gregory A
AU  - Talavera GA
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Thai, Ashley
AU  - Thai A
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Youngblood, Marston E
AU  - Youngblood ME
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
FAU - Rodriguez, Carlos J
AU  - Rodriguez CJ
AD  - From the Department of Epidemiology, Mailman School of Public Health, Columbia 
      University, New York, NY (R.T.D., A.T.); Department of Family Medicine and Public 
      Health (M.A.A.) and Graduate School of Public Health (G.A.T.), University of 
      California, San Diego; Department of Biostatistics, University of North Carolina 
      at Chapel Hill (J.C., M.E.Y.); Department of Epidemiology and Population Health, 
      Albert Einstein College of Medicine, New York, NY (R.C.K.); Department of 
      Medicine, University of Illinois, Champaign (A.A.D.); Department of Psychology, 
      Behavioral Medicine Research Center, University of Miami, Coral Gables, FL 
      (B.E.H.); Wake Forest School of Medicine, Wake Forest University, Winston-Salem, 
      NC (J.C.N., K.S., C.J.R.); and Division of Cardiology, Department of Medicine, 
      Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.).
LA  - eng
GR  - R01 DK102932/DK/NIDDK NIH HHS/United States
GR  - R01 HL104199/HL/NHLBI NIH HHS/United States
GR  - N01HC65236/HL/NHLBI NIH HHS/United States
GR  - N01HC65235/HL/NHLBI NIH HHS/United States
GR  - N01HC65234/HL/NHLBI NIH HHS/United States
GR  - N01HC65233/HL/NHLBI NIH HHS/United States
GR  - N01HC65237/HL/NHLBI NIH HHS/United States
GR  - P30 DK020541/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
CIN - Circ Cardiovasc Imaging. 2016 Oct;9(10):. PMID: 27729372
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/blood/diagnosis/*ethnology
MH  - Diabetic Cardiomyopathies/*diagnostic imaging/ethnology/physiopathology
MH  - Diastole
MH  - *Echocardiography, Doppler, Color
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - *Hispanic or Latino
MH  - Humans
MH  - Insulin Resistance/ethnology
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prediabetic State/blood/diagnosis/ethnology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Risk Factors
MH  - Stroke Volume
MH  - Systole
MH  - United States/epidemiology
MH  - *Ventricular Function, Left
PMC - PMC5111817
MID - NIHMS817968
OTO - NOTNLM
OT  - diabetes mellitus
OT  - diabetic cardiomyopathy
OT  - echocardiography
OT  - insulin resistance
OT  - prediabetic state
EDAT- 2016/10/13 06:00
MHDA- 2017/05/10 06:00
PMCR- 2017/10/01
CRDT- 2016/10/13 06:00
PHST- 2016/02/06 00:00 [received]
PHST- 2016/08/26 00:00 [accepted]
PHST- 2016/10/13 06:00 [entrez]
PHST- 2016/10/13 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - CIRCIMAGING.116.005032 [pii]
AID - 10.1161/CIRCIMAGING.116.005032 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2016 Oct;9(10):e005032. doi: 
      10.1161/CIRCIMAGING.116.005032.