PMID- 27729793
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 12
DP  - 2016
TI  - Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment 
      progressing to Alzheimer's disease.
PG  - 2489-2495
AB  - BACKGROUND: Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's 
      disease (AD), so identification of the related risk factors can be helpful. 
      Although the association between type 2 diabetes mellitus (T2DM) and these modest 
      changes in cognition is well established, whether T2DM will promote the 
      transformation of MCI into AD is not a unified conclusion. OBJECTIVE: This study 
      aims to explore the relationship between T2DM and MCI in the elderly population 
      living in the community in Shanghai, People's Republic of China. METHODS: A total 
      of 197 participants were included in the study. They were screened for T2DM, 
      hyperlipidemia, traumatic brain injury, and family history of dementia. The 
      Mini-Mental State Examination and the Montreal Cognitive Assessment were used to 
      assess cognitive function. The diagnosis of AD was made according to Diagnostic 
      and Statistical Manual of Mental Disorders, Fourth Edition, whereas the diagnosis 
      of MCI was made according to Petersen's criteria. Then, we investigated the 
      relation between T2DM and MCI. RESULTS: A total of 82 (41.6%) participants had no 
      cognitive impairment, 82 (41.6%) participants had MCI, and 33 (16.8%) 
      participants had AD. Multivariate logistic regression models demonstrated that 
      T2DM was a risk factor for AD (odds ratio =49.723, 95% CI =21.173-111.987). 
      CONCLUSION: T2DM might be a risk factor for MCI progressing into AD.
FAU - Li, Wei
AU  - Li W
AD  - Alzheimer's Disease and Related Disorders Center; Department of Geriatric 
      Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of 
      Medicine, Shanghai, People's Republic of China.
FAU - Wang, Tao
AU  - Wang T
AD  - Alzheimer's Disease and Related Disorders Center; Department of Geriatric 
      Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of 
      Medicine, Shanghai, People's Republic of China.
FAU - Xiao, Shifu
AU  - Xiao S
AD  - Alzheimer's Disease and Related Disorders Center; Department of Geriatric 
      Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of 
      Medicine, Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20160929
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC5047733
OTO - NOTNLM
OT  - AD
OT  - MCI
OT  - T2DM
OT  - risk factor
EDAT- 2016/10/13 06:00
MHDA- 2016/10/13 06:01
PMCR- 2016/09/29
CRDT- 2016/10/13 06:00
PHST- 2016/10/13 06:00 [entrez]
PHST- 2016/10/13 06:00 [pubmed]
PHST- 2016/10/13 06:01 [medline]
PHST- 2016/09/29 00:00 [pmc-release]
AID - ndt-12-2489 [pii]
AID - 10.2147/NDT.S111298 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2016 Sep 29;12:2489-2495. doi: 10.2147/NDT.S111298. 
      eCollection 2016.