PMID- 27733670
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20200228
IS  - 1552-8456 (Electronic)
IS  - 0193-9459 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Apr
TI  - APOE epsilon4 and Memory Among Patients With Heart Failure.
PG  - 455-472
LID - 10.1177/0193945916670145 [doi]
AB  - Twenty-three percent to 50% of heart failure (HF) patients have memory loss. 
      Objectives were to (a) characterize major allelic frequency of 2 variants in 
      apolipoprotein ( APOE) gene in HF patients, (b) evaluate differences in memory 
      and serum brain-derived neurotrophic factor (BDNF) levels based on APOE epsilon4 
      allele(s), and (c) estimate effect sizes (ESs) and confidence intervals (CIs). In 
      this pilot, 29 HF patients were enrolled and 26 completed. Recall and delayed 
      recall memory were measured at baseline and 12 weeks. Serum was collected at 
      baseline and 8 weeks. Seven (24.1%) patients had APOE epsilon4 allele. No significant 
      differences were found in recall and delayed recall memory or serum BDNF levels 
      based on APOE epsilon4 allele. ESs were small to medium; CIs indicated ES precision was 
      small. Future studies are needed to fully understand how genotypic and 
      neuropsychological phenotypic variables influence response to computerized 
      cognitive training.
FAU - Pressler, Susan J
AU  - Pressler SJ
AD  - 1 Indiana University School of Nursing, Indianapolis, IN, USA.
FAU - Harrison, Jordan M
AU  - Harrison JM
AD  - 2 University of Michigan School of Nursing, Ann Arbor, MI, USA.
FAU - Titler, Marita
AU  - Titler M
AD  - 2 University of Michigan School of Nursing, Ann Arbor, MI, USA.
FAU - Koelling, Todd M
AU  - Koelling TM
AD  - 3 University of Michigan School of Medicine, Division of Internal Medicine, 
      Cardiology, Ann Arbor, MI, USA.
FAU - Jung, Miyeon
AU  - Jung M
AD  - 1 Indiana University School of Nursing, Indianapolis, IN, USA.
FAU - Dorsey, Susan G
AU  - Dorsey SG
AD  - 4 University of Maryland School of Nursing, Baltimore, MD, USA.
FAU - Bakoyannis, Giorgos
AU  - Bakoyannis G
AD  - 5 Indiana University School of Medicine, Department of Biostatistics, 
      Indianapolis, IN, USA.
FAU - Riley, Penny L
AU  - Riley PL
AD  - 2 University of Michigan School of Nursing, Ann Arbor, MI, USA.
FAU - Hoyland-Domenico, Lisa
AU  - Hoyland-Domenico L
AD  - 6 University of Florida College of Public Health and Health Professions and 
      College of Medicine, Gainesville, FL, USA.
FAU - Giordani, Bruno
AU  - Giordani B
AD  - 7 University of Michigan School of Medicine, Neuropsychology Section, Department 
      of Psychiatry, Neurology, and Psychology, Ann Arbor, MI, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20161012
PL  - United States
TA  - West J Nurs Res
JT  - Western journal of nursing research
JID - 7905435
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Alleles
MH  - Apolipoprotein E4/*genetics
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cognition/physiology
MH  - Female
MH  - *Genotype
MH  - Heart Failure/*genetics
MH  - Humans
MH  - Male
MH  - Memory/*physiology
MH  - Mental Recall/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - APOE epsilon4
OT  - BDNF
OT  - apolipoprotein E
OT  - brain-derived neurotrophic factor
OT  - cognition
OT  - heart failure
OT  - memory
EDAT- 2016/10/14 06:00
MHDA- 2018/11/27 06:00
CRDT- 2016/10/14 06:00
PHST- 2016/10/14 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2016/10/14 06:00 [entrez]
AID - 0193945916670145 [pii]
AID - 10.1177/0193945916670145 [doi]
PST - ppublish
SO  - West J Nurs Res. 2017 Apr;39(4):455-472. doi: 10.1177/0193945916670145. Epub 2016 
      Oct 12.