PMID- 27734127
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20221207
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 57
IP  - 1
DP  - 2018 Feb
TI  - Controlling type-2 diabetes by inclusion of Cr-enriched yeast bread in the daily 
      dietary pattern: a randomized clinical trial.
PG  - 259-267
LID - 10.1007/s00394-016-1315-9 [doi]
AB  - PURPOSE: Chromium (Cr)-enriched yeast supplementation to whole wheat bread 
      (WWCrB) has been shown to ameliorate postprandial glycemic response in healthy 
      subjects. The present study investigates the long-term benefit of WWCrB 
      consumption for patients with type-2 diabetes mellitus (T2DM). METHODS: Thirty 
      patients with T2DM were randomly assigned to a group receiving WWCrB or the plain 
      whole wheat bread (WWB) group. Plasma glucose, insulin, glycosylated hemoglobin 
      (HbA(1c)) and insulin resistance were determined, and oral glucose tolerance test 
      (OGTT) was performed at the beginning and the end of the dietary intervention, 
      which lasted for 12 weeks. Biochemical parameters related to the disease, markers 
      of inflammation as well as body weight and energy balance were examined. RESULTS: 
      At the end of the study, subjects of WWCrB group exerted lower levels of glucose, 
      insulin and HbA(1c) and improved insulin resistance (P < 0.05 against before 
      treatment). Area under the glucose curve attained during OGTT decreased after the 
      intervention (28,117.5 +/- 1266.4 vs. 31,588.5 +/- 1187.5 mg min/dL before treatment, 
      P < 0.05) with significantly lower values of glucose concentration at 0 and 
      60 min. A significant reduction in body weight and systolic blood pressure (SBP) 
      was observed (P < 0.05 against before treatment). Markers of inflammation and 
      lipid profiles were not affected by WWCrB consumption. CONCLUSIONS: Inclusion of 
      WWCrB in the daily dietary pattern of diabetic patients resulted in improvement 
      of glucose tolerance and insulin resistance, significant reduction in HbA(1c), 
      weight loss and lower SBP. Patients with inadequate glycemic control may benefit 
      from the consumption of WWCrB.
FAU - Yanni, Amalia E
AU  - Yanni AE
AD  - Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of 
      Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Ave, 
      176 71, Athens, Greece. ayanni@hua.gr.
FAU - Stamataki, Nikoleta S
AU  - Stamataki NS
AD  - Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of 
      Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Ave, 
      176 71, Athens, Greece.
FAU - Konstantopoulos, Panagiotis
AU  - Konstantopoulos P
AD  - Laboratory of Experimental Surgery and Surgery Research, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Stoupaki, Maria
AU  - Stoupaki M
AD  - Diabetes Laboratory, 1st Pathological Clinic, Laiko University Hospital, School 
      of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Abeliatis, Athanasios
AU  - Abeliatis A
AD  - ELBISCO S.A. Industrial and Commercial Food Company, 21st km Pikermi, Attiki, 
      Greece.
FAU - Nikolakea, Irene
AU  - Nikolakea I
AD  - Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of 
      Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Ave, 
      176 71, Athens, Greece.
FAU - Perrea, Despoina
AU  - Perrea D
AD  - Laboratory of Experimental Surgery and Surgery Research, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Karathanos, Vaios T
AU  - Karathanos VT
AD  - Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of 
      Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Ave, 
      176 71, Athens, Greece.
FAU - Tentolouris, Nikolaos
AU  - Tentolouris N
AD  - Diabetes Laboratory, 1st Pathological Clinic, Laiko University Hospital, School 
      of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161012
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Placebos)
RN  - 0R0008Q3JB (Chromium)
SB  - IM
MH  - Aged
MH  - Blood Glucose/analysis
MH  - *Bread/analysis
MH  - Chromium/*administration & dosage/analysis/blood
MH  - Diabetes Mellitus, Type 2/blood/*diet therapy
MH  - Diet
MH  - Female
MH  - Food, Fortified
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Placebos
MH  - *Saccharomyces cerevisiae/chemistry/metabolism
MH  - Single-Blind Method
MH  - Triticum
OTO - NOTNLM
OT  - Bread
OT  - Cr-enriched yeast
OT  - Glucose tolerance
OT  - Insulin resistance
OT  - Type-2 diabetes mellitus
OT  - Weight management
EDAT- 2016/10/14 06:00
MHDA- 2018/08/28 06:00
CRDT- 2016/10/14 06:00
PHST- 2016/06/15 00:00 [received]
PHST- 2016/09/25 00:00 [accepted]
PHST- 2016/10/14 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2016/10/14 06:00 [entrez]
AID - 10.1007/s00394-016-1315-9 [pii]
AID - 10.1007/s00394-016-1315-9 [doi]
PST - ppublish
SO  - Eur J Nutr. 2018 Feb;57(1):259-267. doi: 10.1007/s00394-016-1315-9. Epub 2016 Oct 
      12.