PMID- 27734141
OWN - NLM
STAT- MEDLINE
DCOM- 20180125
LR  - 20221207
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 408
IP  - 28
DP  - 2016 Nov
TI  - Rapid determination of some beta-blockers in complicated matrices by tandem 
      dispersive liquid-liquid microextraction followed by high performance liquid 
      chromatography.
PG  - 8163-8176
AB  - In this research work, an efficient tandem dispersive liquid-liquid 
      microextraction (TDLLME) procedure coupled with high performance liquid 
      chromatography-ultraviolet detection (HPLC-UV) was successfully applied for 
      the determination of beta-blockers in human plasma and pharmaceutical wastewater 
      samples. High clean-up and preconcentration factor are easily and rapidly 
      feasible via this novel, cheap, and safe microextraction method, leading to high 
      quality experimental data. It consists of two sequential dispersive liquid-liquid 
      microextraction methods, accomplished via air/ultrasonic agitation and air 
      agitation, respectively. In order to enrich the optimal values for the mentioned 
      procedures, the Box-Behnken design (BBD) combined with the desirability function 
      (DF) was used. The optimum values were found to be 11.0 % (w/v) of the salt 
      amount, an initial pH value of 12.0, 103 muL of organic extractant phase, and 
      45 muL of aqueous extractant phase with pH value of 2.0, resulted in reasonable 
      recovery percentages with a logical desirability. Under optimal experimental 
      conditions, good linear ranges (3-2000 ng mL(-1) for metoprolol and 
      2.5-2500 ng mL(-1) for propranolol with the correlation of determinations (R 
      (2)s) higher than 0.99) and low limits of detection (0.8 and 1.0 ng mL(-1) for 
      propranolol and metoprolol, respectively) were obtainable. Also, TDLLME-HPLC-UV 
      provided good proper repeatabilities (relative standard deviations (RSDs) below 
      5.7 %, n = 3) and high enrichment factors (EFs) of 75-100. Graphical abstract 
      TDLLME of beta-blockers from complicated matrices.
FAU - Hemmati, Maryam
AU  - Hemmati M
AD  - Department of Chemistry, Semnan University, Semnan, 2333383-193, Iran.
FAU - Asghari, Alireza
AU  - Asghari A
AD  - Department of Chemistry, Semnan University, Semnan, 2333383-193, Iran. 
      aasghari@semnan.ac.ir.
FAU - Bazregar, Mohammad
AU  - Bazregar M
AD  - Department of Chemistry, Semnan University, Semnan, 2333383-193, Iran.
FAU - Rajabi, Maryam
AU  - Rajabi M
AD  - Department of Chemistry, Semnan University, Semnan, 2333383-193, Iran.
LA  - eng
PT  - Journal Article
DEP - 20161012
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adrenergic beta-Antagonists/analysis/*blood
MH  - Analysis of Variance
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - Limit of Detection
MH  - Liquid Phase Microextraction
MH  - Time Factors
MH  - Wastewater/*chemistry
MH  - Water Pollutants, Chemical/analysis/*blood
OTO - NOTNLM
OT  - Beta-blockers
OT  - Box-Behnken design
OT  - Complicated matrices
OT  - Developed liquid-phase microextraction
OT  - High clean-up and preconcentration
EDAT- 2016/10/22 06:00
MHDA- 2018/01/26 06:00
CRDT- 2016/10/14 06:00
PHST- 2016/04/20 00:00 [received]
PHST- 2016/09/01 00:00 [accepted]
PHST- 2016/08/05 00:00 [revised]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2018/01/26 06:00 [medline]
PHST- 2016/10/14 06:00 [entrez]
AID - 10.1007/s00216-016-9922-0 [pii]
AID - 10.1007/s00216-016-9922-0 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2016 Nov;408(28):8163-8176. doi: 10.1007/s00216-016-9922-0. 
      Epub 2016 Oct 12.