PMID- 27735728
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20191210
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 93
IP  - 1
DP  - 2017 Jan
TI  - Investigation of the influence of calibration practices on cytogenetic laboratory 
      performance for dose estimation.
PG  - 118-126
LID - 10.1080/09553002.2016.1213455 [doi]
AB  - PURPOSE: In the frame of the QA program of RENEB, an inter-laboratory comparison 
      (ILC) of calibration sources used in biological dosimetry was achieved to 
      investigate the influence of calibration practices and protocols on the results 
      of the dose estimation performance as a first step to harmonization and 
      standardization of dosimetry and irradiation practices in the European biological 
      dosimetry network. MATERIALS AND METHODS: Delivered doses by irradiation 
      facilities used by RENEB partners were determined with EPR/alanine dosimetry 
      system. Dosimeters were irradiated in the same conditions as blood samples. A 
      short survey was also performed to collect the information needed for the data 
      analysis and evaluate the diversity of practices. RESULTS: For most of partners 
      the deviation of delivered dose from the targeted dose remains below 10%. 
      Deviations larger than 10% were observed for five facilities out of 21. Origins 
      of the largest discrepancies were identified. Correction actions were evaluated 
      as satisfactory. The re-evaluation of some ILC results for the fluorescence in 
      situ hybridization (FISH) and premature chromosome condensation (PCC) assays has 
      been performed leading to an improvement of the overall performances. 
      CONCLUSIONS: This work has shown the importance of dosimetry in radiobiology 
      studies and the needs of harmonization, standardization in irradiation and 
      dosimetry practices and educational training for biologists using ionizing 
      radiation.
FAU - Trompier, Francois
AU  - Trompier F
AD  - a Institut de Radioprotection et de Surete Nucleaire (IRSN) , Fontenay-aux-roses, 
      France.
FAU - Baumann, Marion
AU  - Baumann M
AD  - a Institut de Radioprotection et de Surete Nucleaire (IRSN) , Fontenay-aux-roses, 
      France.
FAU - Barrios, Lleonard
AU  - Barrios L
AD  - b Universitat Autonoma de Barcelona , Bellaterra , Spain.
FAU - Gregoire, Eric
AU  - Gregoire E
AD  - a Institut de Radioprotection et de Surete Nucleaire (IRSN) , Fontenay-aux-roses, 
      France.
FAU - Abend, Michael
AU  - Abend M
AD  - c Bundeswehr Institut fur Radiologie in verbindung mit der Universtitat Ulm , 
      Germany.
FAU - Ainsbury, Elizabeth
AU  - Ainsbury E
AD  - d Public Health England Centre for Radiation , Chemical and Environmental Hazards 
      (PHE) , Chilton , UK.
FAU - Barnard, Stephen
AU  - Barnard S
AD  - d Public Health England Centre for Radiation , Chemical and Environmental Hazards 
      (PHE) , Chilton , UK.
FAU - Barquinero, Joan Francesc
AU  - Barquinero JF
AD  - c Bundeswehr Institut fur Radiologie in verbindung mit der Universtitat Ulm , 
      Germany.
FAU - Bautista, Juan Antonio
AU  - Bautista JA
AD  - e Hospital Universitario y Politecnico la Fe de Valencia , Valencia , Spain.
FAU - Brzozowska, Beata
AU  - Brzozowska B
AD  - f Stockholm University , Department of Molecular Biosciences , Stockholm , 
      Sweden.
FAU - Perez-Calatayud, Jose
AU  - Perez-Calatayud J
AD  - e Hospital Universitario y Politecnico la Fe de Valencia , Valencia , Spain.
FAU - De Angelis, Cinzia
AU  - De Angelis C
AD  - g Istituto Superiore di Sanita (ISS) , Rome , Italy.
FAU - Dominguez, Inmaculada
AU  - Dominguez I
AD  - h University of Sevilla , Sevilla , Spain.
FAU - Hadjidekova, Valeria
AU  - Hadjidekova V
AD  - i National Center for Radiobiology and Radiation Protection , Sofia , Bulgaria.
FAU - Kulka, Ulrike
AU  - Kulka U
AD  - j Bundesamt fuer Strahlenschutz , Department Radiation Protection and Health , 
      Neuherberg , Germany.
FAU - Mateos, Juan Carlos
AU  - Mateos JC
AD  - h University of Sevilla , Sevilla , Spain.
FAU - Meschini, Roberta
AU  - Meschini R
AD  - k University of Tuscia , Viterbo , Italy.
FAU - Monteiro Gil, Octavia
AU  - Monteiro Gil O
AD  - l Centro de Ciencias e Tecnologias Nucleares , Instituto Superior Tecnico, 
      Universidade de Lisboa , Bobadela-LRS , Portugal.
FAU - Moquet, Jayne
AU  - Moquet J
AD  - d Public Health England Centre for Radiation , Chemical and Environmental Hazards 
      (PHE) , Chilton , UK.
FAU - Oestreicher, Ursula
AU  - Oestreicher U
AD  - j Bundesamt fuer Strahlenschutz , Department Radiation Protection and Health , 
      Neuherberg , Germany.
FAU - Montoro Pastor, Alegria
AU  - Montoro Pastor A
AD  - e Hospital Universitario y Politecnico la Fe de Valencia , Valencia , Spain.
FAU - Quintens, Roel
AU  - Quintens R
AD  - m Belgian Nuclear Research Centre (SCK-CEN) , Mol , Belgium.
FAU - Sebastia, Natividad
AU  - Sebastia N
AD  - e Hospital Universitario y Politecnico la Fe de Valencia , Valencia , Spain.
FAU - Sommer, Sylwester
AU  - Sommer S
AD  - n Institute of Nuclear Chemistry and Technology , Warsaw , Poland.
FAU - Stoyanov, Orlin
AU  - Stoyanov O
AD  - k University of Tuscia , Viterbo , Italy.
FAU - Thierens, Hubert
AU  - Thierens H
AD  - o Faculty of Medicine and Health Sciences , Ghent University , Gent , Belgium.
FAU - Terzoudi, Georgia
AU  - Terzoudi G
AD  - p National Centre for Scientific Research "Demokritos" , Health Physics, 
      Radiobiology & Cytogenetics , Athens , Greece.
FAU - Villaescusa, Juan Ignacio
AU  - Villaescusa JI
AD  - e Hospital Universitario y Politecnico la Fe de Valencia , Valencia , Spain.
FAU - Vral, Anne
AU  - Vral A
AD  - o Faculty of Medicine and Health Sciences , Ghent University , Gent , Belgium.
FAU - Wojcik, Andrzej
AU  - Wojcik A
AD  - f Stockholm University , Department of Molecular Biosciences , Stockholm , 
      Sweden.
FAU - Zafiropoulos, Demetre
AU  - Zafiropoulos D
AD  - q Laboratori Nazionali di Legnaro , INFN , Italy.
FAU - Roy, Laurence
AU  - Roy L
AD  - a Institut de Radioprotection et de Surete Nucleaire (IRSN) , Fontenay-aux-roses, 
      France.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Validation Study
DEP - 20161013
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Calibration/*standards
MH  - Cytogenetic Analysis/*standards/statistics & numerical data
MH  - Europe
MH  - Humans
MH  - Laboratories/standards/*statistics & numerical data
MH  - Practice Guidelines as Topic
MH  - Quality Assurance, Health Care/*standards
MH  - Radiation Dosage
MH  - Radiation Exposure/*analysis
MH  - Radiation Monitoring/*standards/statistics & numerical data
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Alanine dosimetry
OT  - biological dosimetry
OT  - calibration
OT  - inter-laboratory comparison
OT  - quality assurance
EDAT- 2016/10/14 06:00
MHDA- 2017/07/18 06:00
CRDT- 2016/10/14 06:00
PHST- 2016/10/14 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
PHST- 2016/10/14 06:00 [entrez]
AID - 10.1080/09553002.2016.1213455 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2017 Jan;93(1):118-126. doi: 10.1080/09553002.2016.1213455. 
      Epub 2016 Oct 13.