PMID- 27737458
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20220317
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 13
DP  - 2016 Oct 1
TI  - Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Are Reduced in 
      Children With Type 1 Diabetes With No Evidence of Vascular Retinopathy.
PG  - 5355-5360
LID - 10.1167/iovs.16-19988 [doi]
AB  - PURPOSE: To determine whether type 1 diabetes (T1DM) in children with a mean age 
      of 12.21 +/- 3.04 years affects the retinal nerve fiber layer (RNFL) and ganglion 
      cell complex (GCC) when compared to age- and sex-matched healthy children. 
      METHODS: Forty-six children with T1DM with no diabetic retinopathy (DR) and 50 
      normal age- and sex-matched controls underwent full clinical ophthalmic and 
      spectral-domain optical coherence tomography (SD-OCT) examination. Using RTVue 
      Fourier-Domain OCT (version 6.11.0.12) average, superior, and inferior RNFL and 
      GCC thicknesses (in mum) were measured. Mean values of patients and the control 
      group were compared. RESULTS: In children with T1DM with no DR, the mean average 
      RNFL thickness was 110.9 mum +/- 10.46, and the mean GCC thickness was 95.59 mum +/- 
      5.13; both were significantly thinner than the control group (115.62 mum and 99.30 
      mum, respectively). The retinal nerve fiber layer and GCC thickness showed no 
      correlation to either age of onset, duration of the disease, or glycosylated 
      hemoglobin (HbA1c). A positive correlation was found between the daily insulin 
      dose and the average RNFL thickness (r = 0.378, P = 0.01). The average GCC in 
      children with dyslipidemia was thinner than those with normal lipid profile 
      (91.29 +/- 6.46 mum, 97.11 +/- 3.59 mum, respectively) with a P value of 0.011. 
      CONCLUSIONS: Thinning of the RNFL and GCC in children with T1DM with no DR 
      compared to healthy controls suggests that neurodegenerative changes occur in the 
      absence of vascular changes. It also shows that neurodegeneration is not related 
      to either disease duration, onset, or control.
FAU - El-Fayoumi, Dina
AU  - El-Fayoumi D
AD  - Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Badr Eldine, Nashwa M
AU  - Badr Eldine NM
AD  - Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Esmael, Amanne F
AU  - Esmael AF
AD  - Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Ghalwash, Dalia
AU  - Ghalwash D
AD  - Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Soliman, Hend M
AU  - Soliman HM
AD  - Diabetes, Endocrine, & Metabolism Pediatric Unit (DEMPU), Pediatric Department, 
      Faculty of Medicine, Cairo University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*diagnosis
MH  - Diabetic Retinopathy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Ophthalmoscopy
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
EDAT- 2016/10/14 06:00
MHDA- 2017/05/27 06:00
CRDT- 2016/10/14 06:00
PHST- 2016/10/14 06:00 [entrez]
PHST- 2016/10/14 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
AID - 2569574 [pii]
AID - 10.1167/iovs.16-19988 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5355-5360. doi: 
      10.1167/iovs.16-19988.