PMID- 27738550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2157-6998 (Print)
IS  - 2157-7005 (Electronic)
IS  - 2157-7005 (Linking)
VI  - 6
IP  - 4
DP  - 2016 Oct
TI  - Propofol-Related Infusion Syndrome in the Peripartum Period.
PG  - e368-e371
AB  - Background Propofol is a widely known, commonly used drug. Complications can 
      occur with the use of this drug, including propofol-related infusion syndrome 
      (PRIS). PRIS, in the obstetric population, has not been documented; however, we 
      report a case of a patient who developed PRIS after an emergent cesarean delivery 
      of a preterm infant. Case Study A 35-year-old multigravida woman presented 
      complaining of leakage of fluid and decreased fetal movement. Her pregnancy was 
      complicated by methadone maintenance therapy due to a history of opioid abuse. 
      Complications after admission for prolonged monitoring and a prolonged fetal 
      heart tone deceleration was noted with no recovery despite intrauterine 
      resuscitation. An emergent cesarean delivery was performed using general 
      anesthesia and endotracheal intubation after which she developed aspiration 
      pneumonia. She was admitted to the intensive care unit and reintubation and 
      sedation were required secondary to respiratory distress. Sedation was achieved 
      using propofol infusion. She subsequently developed changes in her 
      electrocardiogram, an increase of her serum creatinine, creatinine protein 
      kinase, lipase, amylase, and triglycerides, making the diagnosis of PRIS. 
      Conclusion PRIS should be included in the differential diagnosis of intubated or 
      postoperative patients in the obstetric population.
FAU - Eziefule, Akwugo A
AU  - Eziefule AA
AD  - Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, 
      University of Texas Health Science Center at Houston, Houston, Texas.
FAU - Elshatanoufy, Solafa
AU  - Elshatanoufy S
AD  - Division of Female Pelvic Medicine and Reproductive Surgery, Department of 
      Obstetrics and Gynecology, Henry Ford Health Systems, Detroit, Michigan.
FAU - Thakur, Mili
AU  - Thakur M
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics 
      and Gynecology, Wayne State University School of Medicine, Detroit, Michigan; 
      Division of Genetic and Metabolic Disorders, Department of Pediatrics and Center 
      for Molecular Medicine and Genetics, Wayne State University School of Medicine, 
      Detroit, Michigan.
FAU - Rocha, Frederico G
AU  - Rocha FG
AD  - Department of Obstetrics and Gynecology, Hurley Medical Center, Michigan State 
      University College of Human Medicine, Flint, Michigan.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - AJP Rep
JT  - AJP reports
JID - 101569862
PMC - PMC5061574
OTO - NOTNLM
OT  - PRIS
OT  - infusion syndrome
OT  - obstetrics
OT  - pregnancy
COIS- Conflict of Interest None.
EDAT- 2016/10/16 06:00
MHDA- 2016/10/16 06:01
PMCR- 2016/10/01
CRDT- 2016/10/15 06:00
PHST- 2016/10/15 06:00 [entrez]
PHST- 2016/10/16 06:00 [pubmed]
PHST- 2016/10/16 06:01 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 160041 [pii]
AID - 10.1055/s-0036-1593405 [doi]
PST - ppublish
SO  - AJP Rep. 2016 Oct;6(4):e368-e371. doi: 10.1055/s-0036-1593405.