PMID- 27739612
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 38
IP  - 2
DP  - 2017 Feb
TI  - Structural and functional connectivity of the precuneus and thalamus to the 
      default mode network.
PG  - 938-956
LID - 10.1002/hbm.23429 [doi]
AB  - Neuroimaging studies have identified functional interactions between the 
      thalamus, precuneus, and default mode network (DMN) in studies of consciousness. 
      However, less is known about the structural connectivity of the precuneus and 
      thalamus to regions within the DMN. We used diffusion tensor imaging (DTI) to 
      parcellate the precuneus and thalamus based on their probabilistic white matter 
      connectivity to each other and DMN regions of interest (ROIs) in 37 healthy 
      subjects from the Human Connectome Database. We further assessed resting-state 
      functional connectivity (RSFC) among the precuneus, thalamus, and DMN ROIs. The 
      precuneus was found to have the greatest structural connectivity with the 
      thalamus, where connection fractional anisotropy (FA) increased with age. The 
      precuneus also showed significant structural connectivity to the hippocampus and 
      middle pre-frontal cortex, but minimal connectivity to the angular gyrus and 
      midcingulate cortex. In contrast, the precuneus exhibited significant RSFC with 
      the thalamus and the strongest RSFC with the AG. Significant symmetrical 
      structural connectivity was found between the thalamus and hippocampus, mPFC, 
      sFG, and precuneus that followed known thalamocortical pathways, while thalamic 
      RSFC was strongest with the precuneus and hippocampus. Overall, these findings 
      reveal high levels of structural and functional connectivity linking the 
      thalamus, precuneus, and DMN. Differences between structural and functional 
      connectivity (such as between the precuneus and AG) may be interpreted to reflect 
      dynamic shifts in RSFC for cortical hub-regions involved with consciousness, but 
      could also reflect the limitations of DTI to detect superficial white matter 
      tracts that connect cortico-cortical regions. Hum Brain Mapp 38:938-956, 2017. (c) 
      2016 Wiley Periodicals, Inc.
CI  - Published 2016. This article is a U.S. Government work and is in the public 
      domain in the USA.
FAU - Cunningham, Samantha I
AU  - Cunningham SI
AD  - National Institutes of Health, NIAAA, Bethesda, Maryland.
FAU - Tomasi, Dardo
AU  - Tomasi D
AD  - National Institutes of Health, NIAAA, Bethesda, Maryland.
FAU - Volkow, Nora D
AU  - Volkow ND
AD  - National Institutes of Health, NIAAA, Bethesda, Maryland.
AD  - National Institute of Health, NIDA, Bethesda, Maryland.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20161014
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - *Connectome
MH  - Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Models, Neurological
MH  - Multivariate Analysis
MH  - Nerve Fibers, Myelinated
MH  - Neural Pathways/diagnostic imaging/*physiology
MH  - Parietal Lobe/diagnostic imaging/*physiology
MH  - Rest
MH  - Thalamus/diagnostic imaging/*physiology
MH  - Young Adult
PMC - PMC6866740
OTO - NOTNLM
OT  - Human Connectome Project
OT  - default mode network
OT  - diffusion tensor imaging
OT  - precuneus
OT  - resting-state fMRI
OT  - thalamus
EDAT- 2016/10/16 06:00
MHDA- 2018/02/13 06:00
PMCR- 2016/10/14
CRDT- 2016/10/15 06:00
PHST- 2015/08/17 00:00 [received]
PHST- 2016/08/15 00:00 [revised]
PHST- 2016/09/27 00:00 [accepted]
PHST- 2016/10/16 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2016/10/15 06:00 [entrez]
PHST- 2016/10/14 00:00 [pmc-release]
AID - HBM23429 [pii]
AID - 10.1002/hbm.23429 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2017 Feb;38(2):938-956. doi: 10.1002/hbm.23429. Epub 2016 Oct 14.