PMID- 27741477
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 121
DP  - 2016 Nov
TI  - Interleukin-18 gene polymorphism and risk of CVD in older patients with type 2 
      diabetes mellitus.
PG  - 178-183
LID - S0168-8227(16)30668-4 [pii]
LID - 10.1016/j.diabres.2016.09.021 [doi]
AB  - OBJECTIVE: Interleukin-18 (IL-18), a proinflammatory cytokine, plays a key role 
      in the acute and chronic inflammatory processes. It is associated with risk of 
      developing cardiovascular disease (CVD). The aim of this study was to evaluate 
      association between G(-137)C polymorphism (rs187238) in the IL-18 gene and risk 
      of diabetes and CVD in type 2 diabetes patients. METHODS: We examined 1548 T2DM 
      patients and 590 controls. All subjects were genotyped for the G(-137)C promoter 
      region polymorphism by polymerase chain reaction (PCR-SSP). RESULTS: Genotype 
      distribution of the G(-137)C polymorphism showed no significant difference 
      between T2DM patients and controls (p=0.115). An association with CVD was 
      analyzed in two age groups: ⩾65 and <65years. In patients younger than 65years 
      there was a tendency to association of CC genotype with CAD (OR 1.87, 95% CI 
      1.0-3, p=0.051). In contrast, in subjects aged 65 or older, the C allele and CC 
      genotype showed the significant association with the presence of CVD, with the OR 
      1.99, p=0.001 and OR 5.31, p=0.006, respectively. The C allele carriers showed 
      the higher prevalence of CVD compared to non-carriers (61% vs. 39%, p<0.0001). 
      CONCLUSION: Older T2DM patients carrying the C allele of IL-18 G(-137)C 
      polymorphism have a significantly increased risk of CVD.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Buraczynska, Monika
AU  - Buraczynska M
AD  - Department of Nephrology, Medical University of Lublin, Lublin, Poland. 
      Electronic address: monika.buraczynska@umlub.pl.
FAU - Ksiazek, Katarzyna
AU  - Ksiazek K
AD  - Department of Nephrology, Medical University of Lublin, Lublin, Poland.
FAU - Zukowski, Pawel
AU  - Zukowski P
AD  - Department of Nephrology, Medical University of Lublin, Lublin, Poland.
FAU - Grzebalska, Agnieszka
AU  - Grzebalska A
AD  - Department of Nephrology, Medical University of Lublin, Lublin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160930
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Interleukin-18)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Cardiovascular Diseases/blood/epidemiology/*genetics
MH  - DNA/*genetics
MH  - Diabetes Mellitus, Type 2/blood/complications/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Incidence
MH  - Interleukin-18/blood/*genetics
MH  - Male
MH  - Middle Aged
MH  - Poland/epidemiology
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - G(-137)C polymorphism
OT  - IL-18
OT  - Risk allele
OT  - Type 2 diabetes
EDAT- 2016/10/16 06:00
MHDA- 2017/01/18 06:00
CRDT- 2016/10/15 06:00
PHST- 2016/06/06 00:00 [received]
PHST- 2016/09/13 00:00 [revised]
PHST- 2016/09/22 00:00 [accepted]
PHST- 2016/10/16 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
PHST- 2016/10/15 06:00 [entrez]
AID - S0168-8227(16)30668-4 [pii]
AID - 10.1016/j.diabres.2016.09.021 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2016 Nov;121:178-183. doi: 
      10.1016/j.diabres.2016.09.021. Epub 2016 Sep 30.