PMID- 27742302
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 48
IP  - 7
DP  - 2016 Sep
TI  - Kidney Graft Leiomyosarcoma: A Case Report.
PG  - 2379-2383
LID - S0041-1345(16)30295-0 [pii]
LID - 10.1016/j.transproceed.2016.06.005 [doi]
AB  - BACKGROUND: Kidney transplant (KT) recipients have a higher incidence of 
      malignancy than the general population. Smooth muscle tumors (SMT), including 
      leiomyosarcoma, are rare in kidney transplant recipients, and most cases are 
      associated with Epstein-Barr virus (EBV) infection. CASE REPORT: A 57-year-old 
      man received a deceased donor kidney transplant at the age of 53 years, with 5 
      human leukocyte antigen (HLA) mismatches. Before the transplantation, the patient 
      was IgG positive for EBV viral capsid antigen (VCA), negative for IgM EBV VCA, 
      and also negative for IgG EBV nuclear antigen (EBNA), suggesting a prior EBV 
      infection. He received immunosuppressive induction with basiliximab, and 
      maintenance with tacrolimus, mycophenolate mofetil, and prednisolone. Two years 
      after transplantation, he had an acute cellular rejection episode treated with 
      methylprednisolone. An increased graft size was found 4 years after 
      transplantation. A computed tomographic scan showed 3 solid tumors involving the 
      renal graft with extension to the perinephric fat; no secondary localizations 
      were found. A nephrectomy of the graft was performed. The histologic diagnosis 
      was a high-grade leiomyosarcoma. In situ hybridization for EBV was negative. Nine 
      months after nephrectomy, local recurrence was diagnosed. The surgical approach 
      was unsuccessful, and the patient died after a brief period. CONCLUSION: Kidney 
      leiomyosarcoma is a very rare clinical condition. Most of these neoplasms that 
      arise in transplanted recipients are associated with EBV in tumor tissue. Only 
      one case of renal graft leiomyosarcoma without EBV RNA in the tumor has been 
      previously reported.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Laranjinha, I
AU  - Laranjinha I
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal. 
      Electronic address: ivolaranjinha@gmail.com.
FAU - Matias, P
AU  - Matias P
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
FAU - Jorge, C
AU  - Jorge C
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
FAU - Birne, R
AU  - Birne R
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
FAU - Weigert, A
AU  - Weigert A
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
FAU - Adragao, T
AU  - Adragao T
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
FAU - Bruges, M
AU  - Bruges M
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
FAU - Cabrera, R A
AU  - Cabrera RA
AD  - Department of Pathology, Instituto Portugues de Oncologia de Lisboa Francisco 
      Gentil, Lisboa, Portugal.
FAU - Cassis, J
AU  - Cassis J
AD  - Department of Pathology, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal.
FAU - Ramos, S
AU  - Ramos S
AD  - Department of Pathology, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal.
FAU - Nogueira, A
AU  - Nogueira A
AD  - Department of General Surgery, Centro Hospitalar Lisboa Ocidental, Lisboa, 
      Portugal.
FAU - Godinho, J
AU  - Godinho J
AD  - Department of General Surgery, Centro Hospitalar Lisboa Ocidental, Lisboa, 
      Portugal.
FAU - Messias, H
AU  - Messias H
AD  - Department of General Surgery, Centro Hospitalar Lisboa Ocidental, Lisboa, 
      Portugal.
FAU - Machado, D
AU  - Machado D
AD  - Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Capsid Proteins)
RN  - 0 (Epstein-Barr viral capsid antigen)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Antibodies, Viral/immunology
MH  - Antigens, Viral
MH  - Capsid Proteins
MH  - Epstein-Barr Virus Infections/complications/immunology
MH  - Fatal Outcome
MH  - Graft Rejection/prevention & control
MH  - Herpesvirus 4, Human/immunology
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Neoplasms/*diagnostic imaging/pathology/surgery/virology
MH  - *Kidney Transplantation
MH  - Leiomyosarcoma/*diagnostic imaging/pathology/surgery/virology
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Recurrence, Local
MH  - Tomography, X-Ray Computed
MH  - Transplant Recipients
MH  - Transplants/*diagnostic imaging/pathology/surgery/virology
EDAT- 2016/10/16 06:00
MHDA- 2017/04/04 06:00
CRDT- 2016/10/16 06:00
PHST- 2016/10/16 06:00 [entrez]
PHST- 2016/10/16 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
AID - S0041-1345(16)30295-0 [pii]
AID - 10.1016/j.transproceed.2016.06.005 [doi]
PST - ppublish
SO  - Transplant Proc. 2016 Sep;48(7):2379-2383. doi: 
      10.1016/j.transproceed.2016.06.005.