PMID- 27743116 OWN - NLM STAT- MEDLINE DCOM- 20180716 LR - 20200330 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 27 IP - 11 DP - 2017 Nov TI - Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins. PG - 4612-4618 LID - 10.1007/s00330-016-4616-8 [doi] AB - OBJECTIVES: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. METHODS: Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. RESULTS: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 +/- 1.5 vs. 3.5 +/- 1.6, p < 0.0001) and increased coronary wall enhancement (6.1 +/- 1.1 vs. 4.8 +/- 0.9, p = 0.0027) compared to matched twins with lower BMI. CONCLUSIONS: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. KEY POINTS: * BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. * Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. * In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. * Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis. FAU - Makowski, Marcus R AU - Makowski MR AUID- ORCID: 0000-0001-7719-8236 AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK. AD - Wellcome Trust and EPSRC Medical Engineering Centre, London, UK. AD - BHF Centre of Excellence, King's College London, London, UK. AD - NIHR Biomedical Research Centre, King's College London, London, UK. AD - Department of Radiology, Charite-Universitatsmedizin, Berlin, Germany. FAU - Jansen, Christian H P AU - Jansen CHP AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK. FAU - Ebersberger, Ullrich AU - Ebersberger U AD - Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany. FAU - Schaeffter, Tobias AU - Schaeffter T AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK. AD - Wellcome Trust and EPSRC Medical Engineering Centre, London, UK. AD - BHF Centre of Excellence, King's College London, London, UK. AD - NIHR Biomedical Research Centre, King's College London, London, UK. FAU - Razavi, Reza AU - Razavi R AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK. AD - Wellcome Trust and EPSRC Medical Engineering Centre, London, UK. AD - BHF Centre of Excellence, King's College London, London, UK. AD - NIHR Biomedical Research Centre, King's College London, London, UK. FAU - Mangino, Massimo AU - Mangino M AD - Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. AD - National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK. FAU - Spector, Tim D AU - Spector TD AD - Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany. FAU - Botnar, Rene M AU - Botnar RM AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK. AD - Wellcome Trust and EPSRC Medical Engineering Centre, London, UK. AD - BHF Centre of Excellence, King's College London, London, UK. AD - NIHR Biomedical Research Centre, King's College London, London, UK. FAU - Greil, Gerald F AU - Greil GF AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, London, SE1 7EH, UK. gerald.greil@kcl.ac.uk. AD - Wellcome Trust and EPSRC Medical Engineering Centre, London, UK. gerald.greil@kcl.ac.uk. AD - BHF Centre of Excellence, King's College London, London, UK. gerald.greil@kcl.ac.uk. AD - NIHR Biomedical Research Centre, King's College London, London, UK. gerald.greil@kcl.ac.uk. LA - eng GR - Wellcome Trust/United Kingdom PT - Journal Article PT - Twin Study DEP - 20161014 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM EIN - Eur Radiol. 2017 Jul 4;:. PMID: 28677068 MH - Adult MH - Aged MH - Body Mass Index MH - Contrast Media/pharmacology MH - Coronary Artery Disease/*diagnosis/etiology MH - Coronary Vessels/*pathology MH - *Diseases in Twins MH - Female MH - Gadolinium DTPA/*pharmacology MH - Humans MH - Imaging, Three-Dimensional MH - Magnetic Resonance Imaging/*methods MH - Middle Aged MH - Obesity/*complications/diagnosis MH - ROC Curve MH - *Twins, Monozygotic PMC - PMC5635090 OTO - NOTNLM OT - 3D-IR-TFE OT - Coronary OT - MRI OT - Twin OT - Vessel wall scan EDAT- 2016/10/16 06:00 MHDA- 2018/07/17 06:00 PMCR- 2016/10/14 CRDT- 2016/10/16 06:00 PHST- 2015/10/09 00:00 [received] PHST- 2016/09/22 00:00 [accepted] PHST- 2016/09/09 00:00 [revised] PHST- 2016/10/16 06:00 [pubmed] PHST- 2018/07/17 06:00 [medline] PHST- 2016/10/16 06:00 [entrez] PHST- 2016/10/14 00:00 [pmc-release] AID - 10.1007/s00330-016-4616-8 [pii] AID - 4616 [pii] AID - 10.1007/s00330-016-4616-8 [doi] PST - ppublish SO - Eur Radiol. 2017 Nov;27(11):4612-4618. doi: 10.1007/s00330-016-4616-8. Epub 2016 Oct 14.