PMID- 27743851
OWN - NLM
STAT- MEDLINE
DCOM- 20171012
LR  - 20181202
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 220
IP  - 2 Pt A
DP  - 2017 Mar
TI  - Perfluorinated alkylated substances and brominated flame retardants in serum of 
      the Czech adult population.
PG  - 235-243
LID - S1438-4639(16)30114-6 [pii]
LID - 10.1016/j.ijheh.2016.09.003 [doi]
AB  - Persistent organic pollutants, such as perfluorinated alkylated substances 
      (PFASs) and brominated flame retardants (BFRs) are widespread in the environment 
      and most of them are bioaccumulated in wildlife and humans. The present study is 
      the first investigation to reveal the PFAS and BFR levels of serum samples in the 
      adult population of the Czech Republic. Altogether, 300 serum samples from blood 
      donors in four cities were examined. In all samples 19 PFASs and 33 BFRs, 
      including some of their metabolites, were targeted. The analyses were performed 
      using ultra high performance liquid chromatography coupled with tandem mass 
      spectrometry or gas chromatography with mass spectrometry (according to the type 
      of analyte). PFASs, with the carbon chain length C6 and higher, dominated in all 
      samples. Perfluorooctanesulfonate (PFOS; median: 2.43ng/mL), perfluorooctanoic 
      acid (PFOA; median: 0.756ng/mL), perfluorodecanoic acid (PFDA; median: 
      0.145ng/mL) and perfluorohexanesulfonate (PFHxS; median: 0.184ng/mL) were 
      detected in 100% of samples. Perfluorononanoic acid (PFNA; median: 0.325ng/mL) 
      and perfluoroundecanoic acid (PFUdA; median: 0.058ng/mL) in 99.7% and 96.0% of 
      samples, respectively. We observed statistically significant associations 
      (p<0.05) between selected PFAS concentrations and the locality, gender, age of 
      donors and education level. None of the BFRs was detected above the LOQ in more 
      than 9% of the samples. The most frequently detected representatives of this 
      group were congeners of polybrominated diphenyl ethers, namely BDE-47 (in 8.7%; 
      range: 0.496-5.44ng/g lipid weight (l.w.)), BDE-99 (in 6.0%; range: 
      0.706-9.46ng/g l.w.), BDE-153 (in 7.3%; range: 0.736-6.44ng/g l.w.) and BDE-209 
      (in 7.0%; range: 13.7-2693ng/g l.w.).
CI  - Copyright (c) 2016 Elsevier GmbH. All rights reserved.
FAU - Sochorova, Lenka
AU  - Sochorova L
AD  - National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic. 
      Electronic address: lenka.sochorova@szu.cz.
FAU - Hanzlikova, Lenka
AU  - Hanzlikova L
AD  - National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic.
FAU - Cerna, Milena
AU  - Cerna M
AD  - National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic.
FAU - Drgacova, Anna
AU  - Drgacova A
AD  - National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic.
FAU - Fialova, Alena
AU  - Fialova A
AD  - National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic.
FAU - Svarcova, Andrea
AU  - Svarcova A
AD  - University of Chemistry and Technology, Faculty of Food and Biochemical 
      Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28 
      Prague, Czech Republic.
FAU - Gramblicka, Tomas
AU  - Gramblicka T
AD  - University of Chemistry and Technology, Faculty of Food and Biochemical 
      Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28 
      Prague, Czech Republic.
FAU - Pulkrabova, Jana
AU  - Pulkrabova J
AD  - University of Chemistry and Technology, Faculty of Food and Biochemical 
      Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28 
      Prague, Czech Republic.
LA  - eng
PT  - Journal Article
DEP - 20160928
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Carboxylic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alkanesulfonic Acids/*blood
MH  - Carboxylic Acids/*blood
MH  - Cities
MH  - Czech Republic
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Flame Retardants/*analysis
MH  - Fluorocarbons/*blood
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polybrominated Biphenyls/*blood
MH  - Urban Population
MH  - Young Adult
OTO - NOTNLM
OT  - Brominated flame retardants
OT  - Czech Republic
OT  - Human biomonitoring
OT  - Perfluorinated alkylated substances
OT  - Persistent organic pollutants
EDAT- 2016/10/17 06:00
MHDA- 2017/10/13 06:00
CRDT- 2016/10/17 06:00
PHST- 2016/06/30 00:00 [received]
PHST- 2016/08/15 00:00 [revised]
PHST- 2016/09/05 00:00 [accepted]
PHST- 2016/10/17 06:00 [pubmed]
PHST- 2017/10/13 06:00 [medline]
PHST- 2016/10/17 06:00 [entrez]
AID - S1438-4639(16)30114-6 [pii]
AID - 10.1016/j.ijheh.2016.09.003 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):235-243. doi: 
      10.1016/j.ijheh.2016.09.003. Epub 2016 Sep 28.