PMID- 27744050
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20170417
IS  - 1873-0329 (Electronic)
IS  - 1383-5769 (Linking)
VI  - 66
IP  - 1
DP  - 2017 Feb
TI  - Normal serum IgE levels and eosinophil counts exhibited during Strongyloides 
      stercoralis infection.
PG  - 807-812
LID - S1383-5769(16)30429-9 [pii]
LID - 10.1016/j.parint.2016.10.004 [doi]
AB  - Infections with parasites, such as Strongyloides stercoralis, typically cause 
      elevated levels of serum immunoglobulin E (IgE) and eosinophils; however, 
      co-infection with human T cell lymphotropic virus type 1 (HTLV-1) can cause lower 
      levels of serum IgE during S. stercoralis infection. We conducted this study to 
      determine whether serum IgE levels and eosinophil counts could also be related to 
      other patient characteristics or symptoms. Between 1991 and 2014, we measured and 
      compared the symptoms of 237 patients and evaluated serum IgE levels and 
      eosinophil counts of 199 patients who were infected with S. stercoralis at the 
      Ryukyu University Hospital and the Nishizaki Hospital. Medical records were 
      reviewed and blood samples were taken before treatment with the anthelminthic, 
      ivermectin, 2weeks following the first dosage, and 2weeks following the second 
      dosage. Commonly reported symptoms included abdominal pain, diarrhea, and general 
      fatigue. Serum IgE levels were found to be normal in patients co-infected with 
      HTLV-1. Additionally, females and patients younger than 70years old exhibited 
      normal serum IgE levels when infected with S. stercoralis. No factor included in 
      our analysis was found to affect eosinophil counts. Serum IgE levels can remain 
      within the normal range for some patients infected with S. stercoralis. 
      Therefore, physicians should not eliminate S. stercoralis infection from the 
      differential diagnosis solely according to findings of normal or low IgE levels.
CI  - Copyright A(c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Higashiarakawa, Miwa
AU  - Higashiarakawa M
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Faculty of 
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, 
      Japan; Department of Endoscopy, University of the Ryukyus Hospital, 207 Uehara, 
      Nishihara, Okinawa 903-0215, Japan. Electronic address: 
      higasiarakawa@mail.goo.ne.jp.
FAU - Hirata, Tetsuo
AU  - Hirata T
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Faculty of 
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, 
      Japan.
FAU - Tanaka, Teruhisa
AU  - Tanaka T
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Faculty of 
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, 
      Japan.
FAU - Parrott, Gretchen
AU  - Parrott G
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Faculty of 
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, 
      Japan.
FAU - Kinjo, Tetsu
AU  - Kinjo T
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Faculty of 
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, 
      Japan.
FAU - Naka, Hidekatsu
AU  - Naka H
AD  - Nishizaki Hospital, 371-1 Zaha, Itoman, Okinawa 901-0314, Japan.
FAU - Hokama, Akira
AU  - Hokama A
AD  - Department of Endoscopy, University of the Ryukyus Hospital, 207 Uehara, 
      Nishihara, Okinawa 903-0215, Japan.
FAU - Fujita, Jiro
AU  - Fujita J
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Faculty of 
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20161012
PL  - Netherlands
TA  - Parasitol Int
JT  - Parasitology international
JID - 9708549
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Antinematodal Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 70288-86-7 (Ivermectin)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Animals
MH  - Antibodies, Helminth/*blood
MH  - Antinematodal Agents/therapeutic use
MH  - Asymptomatic Infections
MH  - Coinfection/diagnosis/*immunology/parasitology/virology
MH  - Diagnosis, Differential
MH  - Eosinophils/*immunology
MH  - Female
MH  - HTLV-I Infections/complications/immunology
MH  - Human T-lymphotropic virus 1/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Ivermectin/therapeutic use
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Strongyloides stercoralis/*immunology
MH  - Strongyloidiasis/complications/diagnosis/drug therapy/*immunology
OTO - NOTNLM
OT  - Elderly
OT  - Female
OT  - HTLV-1
OT  - Serum IgE levels
OT  - Strongyloides stercoralis
OT  - Symptom
EDAT- 2016/11/05 06:00
MHDA- 2017/04/18 06:00
CRDT- 2016/11/07 06:00
PHST- 2015/08/25 00:00 [received]
PHST- 2016/08/08 00:00 [revised]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2016/11/05 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
PHST- 2016/11/07 06:00 [entrez]
AID - S1383-5769(16)30429-9 [pii]
AID - 10.1016/j.parint.2016.10.004 [doi]
PST - ppublish
SO  - Parasitol Int. 2017 Feb;66(1):807-812. doi: 10.1016/j.parint.2016.10.004. Epub 
      2016 Oct 12.