PMID- 27748410
OWN - NLM
STAT- MEDLINE
DCOM- 20180517
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Oct 17
TI  - Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 
      8-year study.
PG  - 35368
LID - 10.1038/srep35368 [doi]
LID - 35368
AB  - Lactic acidosis is common in critical care; by contrast, a subtype called 
      alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary 
      purpose of this study was to determine the prognosis of AALA in critically ill 
      patients and the second aim was to determine whether the survival was associated 
      to the peak blood lactate concentration. An 8-year retrospective analysis of 
      adult patients admitted to the intensive care unit (ICU) with AALA between 
      January 2007 and December 2014 was considered in a tertiary care hospital. In 
      total, 23 patients were analyzed and the median peak blood lactate level was 
      15.9 mmol/L. Only 2 patients (8.7%) presented peak blood lactate levels 
      <10 mmol/L. In this study, 21 patients survived from ICU and hospital, the 
      mortality rate was 8.7%. The result indicted the survival of AALA was not 
      associated with peak blood lactate concentration although survivors still had a 
      better lactate clearance rate per hour than non-survivors. Moreover, AALA 
      patients with coexisting sepsis presenting higher lactate clearance rate and 
      shorter lactate clearance time than those of AALA patients with solely 
      sepsis-related lactic acidosis.
FAU - Yang, Chun-Chieh
AU  - Yang CC
AD  - Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Chan, Khee-Siang
AU  - Chan KS
AD  - Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Tseng, Kuei-Ling
AU  - Tseng KL
AD  - Department of Respiratory Therapy, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Weng, Shih-Feng
AU  - Weng SF
AD  - Department of Healthcare Administration and Medical Informatics, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20161017
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Acidosis, Lactic/complications/*physiopathology
MH  - Adult
MH  - Aged
MH  - Alcoholism/complications/*physiopathology
MH  - Critical Care
MH  - Critical Illness
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Intensive Care Units
MH  - Lactic Acid/blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sepsis/blood
MH  - Tertiary Care Centers
PMC - PMC5066311
EDAT- 2016/10/18 06:00
MHDA- 2018/05/18 06:00
PMCR- 2016/10/17
CRDT- 2016/10/18 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/09/27 00:00 [accepted]
PHST- 2016/10/18 06:00 [entrez]
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2018/05/18 06:00 [medline]
PHST- 2016/10/17 00:00 [pmc-release]
AID - srep35368 [pii]
AID - 10.1038/srep35368 [doi]
PST - epublish
SO  - Sci Rep. 2016 Oct 17;6:35368. doi: 10.1038/srep35368.