PMID- 27748501
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20220321
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 24
IP  - 1
DP  - 2017
TI  - Circulating microRNAs as novel biomarkers for dilated cardiomyopathy.
PG  - 65-73
LID - 10.5603/CJ.a2016.0097 [doi]
AB  - BACKGROUND: Circulating microRNAs (miRNAs) potentially carry disease-specific 
      information. In the current study, we aim to characterize the miRNA signature in 
      plasma from dilated cardiomyopathy (DCM) patients and assess the possible 
      correlation between expression levels of circulating miRNAs and symptom severity 
      in DCM patients. METHODS: Using microarray-based miRNA expression profiling, we 
      compared the miRNA expression levels in plasma samples from 4 DCM patients and 3 
      healthy controls. The expression levels of selected differentially expressed, 
      upregulated miRNAs (miR-3135b, miR-3908 and miR-5571-5p) were validated 
      independently in plasma samples from 19 DCM patients and 20 controls. RESULTS: We 
      observed that plasma miR-3135b (p < 0.001), miR-3908 (p < 0.001) and miR-5571-5p 
      (p < 0.001) were significantly upregulated in DCM patients. The area under 
      receiver operating characteristic (ROC) curves for the 3 miRNAs ranged from 0.83 
      to 1.00. Moreover, miR-5571-5p levels in plasma were significantly upregulated 
      with severe New York Heart Association (NYHA) classification (p < 0.05). 
      CONCLUSIONS: The circulating miRNAs (miR-3135b, miR-3908 and miR-5571-5p) have 
      potential as diagnostic biomarkers for DCM. Additionally, miR-5571-5p correlated 
      with NYHA classification.
FAU - Wang, Hua
AU  - Wang H
FAU - Chen, Feng
AU  - Chen F
FAU - Tong, Jiabin
AU  - Tong J
FAU - Li, Yingying
AU  - Li Y
FAU - Cai, Jianping
AU  - Cai J
FAU - Wang, Yan
AU  - Wang Y
FAU - Li, Peng
AU  - Li P
FAU - Hao, Yichun
AU  - Hao Y
FAU - Tian, Weimeng
AU  - Tian W
FAU - Lv, You
AU  - Lv Y
FAU - Chong, Jia
AU  - Chong J
FAU - Yang, Jiefu
AU  - Yang J
AD  - Department of Cardiology, Beijing Hospital, National Center of Ger ontology, 
      100730, Beijing, China. yangjiefu2011@126.com.
LA  - eng
PT  - Journal Article
DEP - 20161017
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Dilated/*blood/diagnosis/genetics
MH  - Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood/genetics
MH  - Middle Aged
MH  - RNA/*genetics
MH  - ROC Curve
MH  - Reverse Transcriptase Polymerase Chain Reaction
OTO - NOTNLM
OT  - biomarkers
OT  - diagnosis
OT  - dilated cardiomyopathy
OT  - microRNAs
EDAT- 2016/11/03 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/10/18 06:00
PHST- 2016/03/20 00:00 [received]
PHST- 2016/10/06 00:00 [accepted]
PHST- 2016/11/02 00:00 [revised]
PHST- 2016/11/03 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/10/18 06:00 [entrez]
AID - VM/OJS/J/45187 [pii]
AID - 10.5603/CJ.a2016.0097 [doi]
PST - ppublish
SO  - Cardiol J. 2017;24(1):65-73. doi: 10.5603/CJ.a2016.0097. Epub 2016 Oct 17.