PMID- 27748730
OWN - NLM
STAT- MEDLINE
DCOM- 20171127
LR  - 20181113
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Linking)
VI  - 95
IP  - 3
DP  - 2017 Mar
TI  - Heterogeneity, functional specialization and differentiation of monocyte-derived 
      dendritic cells.
PG  - 244-251
LID - 10.1038/icb.2016.104 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that consist of 
      functionally and phenotypically heterogeneous populations. Monocyte-derived DCs 
      (moDCs) are a DC subset that have been attracting increasing interest owing to 
      their potent influence on adaptive immune function and their rapid accumulation 
      upon an inflammatory stimulus. Although early studies on moDCs mainly addressed 
      infection, their emergence and function in other settings such as autoimmunity 
      and allogeneic organ transplantation are now being increasingly appreciated. In 
      this review, the relationship between murine monocyte subsets and the moDCs that 
      arise from them is discussed. Their role in initiating and modulating innate and 
      adaptive immune responses in various pathophysiological scenarios is also 
      explored, including how they may separate their labour from conventional DCs. How 
      these findings might relate to their human counterparts is also discussed. 
      Overall, monocytes and moDCs exhibit complex and heterogeneous behaviours that 
      are critical in responses against microbial invasion, autoimmunity and allograft 
      rejection.
FAU - Chow, Kevin V
AU  - Chow KV
AD  - Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 
      Parkville, Victoria, Australia.
AD  - Department of Medical Biology, Parkville, Victoria, Australia.
AD  - Department of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria, 
      Australia.
FAU - Sutherland, Robyn M
AU  - Sutherland RM
AD  - Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 
      Parkville, Victoria, Australia.
AD  - Department of Medical Biology, Parkville, Victoria, Australia.
FAU - Zhan, Yifan
AU  - Zhan Y
AD  - Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 
      Parkville, Victoria, Australia.
AD  - Department of Medical Biology, Parkville, Victoria, Australia.
FAU - Lew, Andrew M
AU  - Lew AM
AD  - Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 
      Parkville, Victoria, Australia.
AD  - Department of Medical Biology, Parkville, Victoria, Australia.
AD  - Department of Microbiology and Immunology, University of Melbourne, Parkville, 
      Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161017
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
SB  - IM
MH  - Animals
MH  - *Cell Differentiation
MH  - Dendritic Cells/*cytology
MH  - Disease
MH  - Humans
MH  - Immunity
MH  - Monocytes/*cytology
EDAT- 2016/10/18 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/10/18 06:00
PHST- 2016/09/04 00:00 [received]
PHST- 2016/10/12 00:00 [revised]
PHST- 2016/10/13 00:00 [accepted]
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/10/18 06:00 [entrez]
AID - icb2016104 [pii]
AID - 10.1038/icb.2016.104 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2017 Mar;95(3):244-251. doi: 10.1038/icb.2016.104. Epub 2016 
      Oct 17.