PMID- 27749004
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20220311
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 16
IP  - 1
DP  - 2017 Jan
TI  - Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder.
PG  - 15-43
LID - 10.1111/gbb.12349 [doi]
AB  - Post-traumatic stress disorder (PTSD) and alcohol-use disorder (AUD) are highly 
      comorbid in humans. Although we have some understanding of the structural and 
      functional brain changes that define each of these disorders, and how those 
      changes contribute to the behavioral symptoms that define them, little is known 
      about the neurobiology of comorbid PTSD and AUD, which may be due in part to a 
      scarcity of adequate animal models for examining this research question. The goal 
      of this review is to summarize the current state-of-the-science on comorbid PTSD 
      and AUD. We summarize epidemiological data documenting the prevalence of this 
      comorbidity, review what is known about the potential neurobiological basis for 
      the frequent co-occurrence of PTSD and AUD and discuss successes and failures of 
      past and current treatment strategies. We also review animal models that aim to 
      examine comorbid PTSD and AUD, highlighting where the models parallel the human 
      condition, and we discuss the strengths and weaknesses of each model. We conclude 
      by discussing key gaps in our knowledge and strategies for addressing them: in 
      particular, we (1) highlight the need for better animal models of the comorbid 
      condition and better clinical trial design, (2) emphasize the need for 
      examination of subpopulation effects and individual differences and (3) urge 
      cross-talk between basic and clinical researchers that is reflected in 
      collaborative work with forward and reverse translational impact.
CI  - (c) 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics 
      Society.
FAU - Gilpin, N W
AU  - Gilpin NW
AD  - Department of Physiology, Louisiana State University Health Sciences Center, New 
      Orleans, LA.
AD  - Neuroscience Center of Excellence, Louisiana State University Health Sciences 
      Center, New Orleans, LA.
FAU - Weiner, J L
AU  - Weiner JL
AD  - Department of Physiology and Pharmacology, Wake Forest School of Medicine, 
      Winston-Salem, NC, USA.
LA  - eng
GR  - R37 AA010422/AA/NIAAA NIH HHS/United States
GR  - R01 AA023305/AA/NIAAA NIH HHS/United States
GR  - P01 AA021099/AA/NIAAA NIH HHS/United States
GR  - R37 AA017531/AA/NIAAA NIH HHS/United States
GR  - R01 AA017531/AA/NIAAA NIH HHS/United States
GR  - R01 AA010422/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20161118
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
SB  - IM
MH  - Alcohol-Induced Disorders, Nervous System/complications/*physiopathology/therapy
MH  - Animals
MH  - Humans
MH  - Stress Disorders, Post-Traumatic/complications/*physiopathology/therapy
PMC - PMC5477640
MID - NIHMS831456
OTO - NOTNLM
OT  - Alcohol dependence
OT  - alcohol use disorder (AUD)
OT  - alcoholism
OT  - amygdala
OT  - comorbid PTSD and AUD
OT  - hippocampus
OT  - mesolimbic reward circuit
OT  - norepinephrine
OT  - post-traumatic stress disorder (PTSD)
OT  - prefrontal cortex
EDAT- 2016/10/18 06:00
MHDA- 2017/06/01 06:00
PMCR- 2018/01/01
CRDT- 2016/10/18 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2016/10/03 00:00 [revised]
PHST- 2016/10/07 00:00 [accepted]
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/10/18 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.1111/gbb.12349 [doi]
PST - ppublish
SO  - Genes Brain Behav. 2017 Jan;16(1):15-43. doi: 10.1111/gbb.12349. Epub 2016 Nov 
      18.