PMID- 27749688
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20221207
IS  - 1744-6880 (Electronic)
IS  - 1744-6872 (Linking)
VI  - 26
IP  - 12
DP  - 2016 Dec
TI  - HLA-A*02 alleles are associated with tetanus antitoxin-induced exanthematous drug 
      eruptions in Chinese patients.
PG  - 538-546
AB  - OBJECTIVE: Tetanus antitoxin (TAT) is an effective antitetanus medicine, but may 
      sometimes cause adverse drug reactions such as rapid-onset anaphylactic shock and 
      late-onset cutaneous adverse drug reactions, including exanthematous drug 
      eruptions (EDE). Human leukocyte antigen (HLA) class I alleles are strongly 
      associated with different types of cutaneous adverse drug reactions. This study 
      aimed to assess whether there is an association between TAT-induced EDE and 
      HLA-A, HLA-B, and HLA-C alleles in the Chinese Han population. PATIENTS AND 
      METHODS: We carried out an association study in 15 patients with TAT-induced EDE 
      and two groups of general Han Chinese patients. Allele-level genotypes of the 
      HLA-A, HLA-B, and HLA-C genes of each patient were determined using the 
      PCR-sequence-specific oligonucleotides method. RESULTS: The carrier frequency of 
      HLA serotype A2 was significantly higher in the TAT-induced EDE patients than in 
      the general Han Chinese study participants from the human major 
      histocompatibility complex database [n=283, odds ratio (OR)=6.93; P=0.0061]. 
      Particularly, the carrier frequency of three A2 alleles, including HLA-A*02:01, 
      HLA-A*02:06, and HLA-A*02:07, is significantly higher than that of the control 
      group (OR=14.40; P=2.4x10). Furthermore, HLA-B*39:01 was in complete linkage 
      disequilibrium with HLA-A*02:06 in the case patients. Consequently, the 
      distribution of the HLA-A*02:06/-B*39:01 haplotype was also significantly 
      different in the cases and the controls (OR=105.00; P=0.0024). CONCLUSION: The 
      HLA-A*02:06/-B*39:01 haplotype is a potential genetic marker for the TAT-induced 
      EDE. Furthermore, the HLA-A2 serotype, especially three alleles A*02:01, A*02:06, 
      and A*02:07, was identified to be associated with the TAT-induced EDE in the Han 
      Chinese population for the first time.
FAU - Yan, Sijia
AU  - Yan S
AD  - aInstitutes of Biomedical Sciences bDepartment of Dermatology, Huashan Hospital 
      cChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Shanghai dDepartment of Pharmacology, School of Medicine, Zhengzhou University, 
      Zhengzhou, China.
FAU - Chen, Sheng-An
AU  - Chen SA
FAU - Zhang, Wen
AU  - Zhang W
FAU - Yang, Fanping
AU  - Yang F
FAU - Yang, Ying
AU  - Yang Y
FAU - Zhu, Qinyuan
AU  - Zhu Q
FAU - Zhu, Huizhong
AU  - Zhu H
FAU - Sun, Xinfen
AU  - Sun X
FAU - Jiang, Menglin
AU  - Jiang M
FAU - Su, Yu
AU  - Su Y
FAU - Zhang, Lirong
AU  - Zhang L
FAU - Xing, Qinghe
AU  - Xing Q
FAU - Luo, Xiaoqun
AU  - Luo X
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacogenet Genomics
JT  - Pharmacogenetics and genomics
JID - 101231005
RN  - 0 (HLA-A Antigens)
RN  - 0 (Tetanus Antitoxin)
SB  - IM
MH  - Adult
MH  - Asian People/ethnology/*genetics
MH  - China/ethnology
MH  - Exanthema/chemically induced/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - HLA-A Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tetanus Antitoxin/*toxicity
EDAT- 2016/10/28 06:00
MHDA- 2017/05/02 06:00
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
AID - 10.1097/FPC.0000000000000248 [doi]
PST - ppublish
SO  - Pharmacogenet Genomics. 2016 Dec;26(12):538-546. doi: 
      10.1097/FPC.0000000000000248.